Tauroursodeoxycholate NEW
| Price | $50 | $63 |
| Package | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-17 |
Product Details
| Product Name: Tauroursodeoxycholate | CAS No.: 14605-22-2 |
| Purity: 99.93% | Supply Ability: 10g |
| Release date: 2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | Tauroursodeoxycholate |
| 描述 | Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans.Tauroursodeoxycholate is being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis. |
| 體外活性 | METHODS: HeLa cells overexpressing the WDR45 mutation were treated with Tauroursodeoxycholate (200 μM) for 24 h, and the expression levels of target proteins were measured by Western Blot. RESULTS: Inhibition of ER stress with Tauroursodeoxycholate significantly reduced the phosphorylation of p38 and LAMP2A as well as the punctate formation of mCherry KFERQ in cells expressing mutant WDR45. [1] METHODS: Undifferentiated neural stem cells NSCs were treated with Tauroursodeoxycholate (100 μM) for 24 h and cell proliferation was detected by Flow cytometry via BrdU. RESULTS: BrdU incorporation increased significantly after incubation with Tauroursodeoxycholate, and Tauroursodeoxycholate regulated cell proliferation. Tauroursodeoxycholate regulates cell proliferation.[2] |
| 體內(nèi)活性 | METHODS: To test the effect on diabetes, Tauroursodeoxycholate (300 mg/kg) was administered intraperitoneally to STZ-induced diabetic C57BL/6 mice once daily for 24 days. RESULTS: After 15 days of treatment, STZ+Tauroursodeoxycholate mice had a 43% reduction in blood glucose compared to the STZ group. This decrease may be due to an increase in insulinemia. [3] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | 5% DMSO+95% Saline : 4.5 mg/mL (9.01 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. DMSO : 6.25 mg/mL (12.51 mM), Sonication is recommended. |
| 關(guān)鍵字 | Endogenous Metabolite | reticulum | ERK | Caspase | caspase-12 | Extracellular signal regulated kinases | molecules | UR906 | inhibit | Apoptosis | UR-906 | endoplasmic | stress | Tauroursodeoxycholate | caspase-3 | Inhibitor |
| 相關(guān)產(chǎn)品 | Sucrose | Tributyrin | Glycerol | Thymidine |
| 相關(guān)庫(kù) | 激酶抑制劑庫(kù) | 藥物功能重定位化合物庫(kù) | 天然產(chǎn)物庫(kù) | 中藥抗炎分子庫(kù) | FDA 上市藥物庫(kù) | 人內(nèi)源代謝化合物庫(kù) | 腸道微生物代謝化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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