Tau-aggregation and neuroinflammation-IN-1 NEW
| Price | $39 | $64 | $122 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: Tau-aggregation and neuroinflammation-IN-1 | CAS No.: 2175953-98-5 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱(chēng) | Tau-aggregation and neuroinflammation-IN-1 |
| 描述 | Tau-aggregation and neuroinflammation-IN-1 is a potent inhibitor of tau protein aggregates, showing significant inhibitory activity against AcPHF6 and full-length tau protein aggregates. It has anti-inflammatory activity, reduces NO release, exhibits low cytotoxicity against LSP-stimulated BV2 cells, and reverses okadaic acid-induced memory impairment in rats. |
| 體外活性 | Tau-aggregation and neuroinflammation-IN-1 (compound 30) (0-40 μM) reduces the survival of SH-SY5Y cells at 30 μM and exhibits no significant hepatotoxicity at high concentrations in LO2 cells, without affecting the viability of BV2 cells at 20 μM. Tau-aggregation and neuroinflammation-IN-1 (2.5, 5, and 10 μM; 24 h) maintain the anti-inflammatory effect of sodium usage and decrease the NO release rate by 41% at 10 μM in LPS-stimulated BV2 cells.[1] |
| 體內(nèi)活性 | Tau-aggregation and neuroinflammation-IN-1 (5 and 10 mg/kg; I.P.; for 7 days, followed by 7 additional days post-OA injection; Male SD rats) significantly enhances spatial memory and cognitive abilities in OA-induced rats.[1] |
| 存儲(chǔ)條件 | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (108.59 mM), Sonication is recommended. |
| 相關(guān)產(chǎn)品 | Flubendazole | L-NAME hydrochloride | Mifepristone | Oxfendazole | L-Arginine | Ethyl cinnamate | Methylene Blue trihydrate | L-Arginine hydrochloride | Paclitaxel |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 微管靶向化合物庫(kù) | 抑制劑庫(kù) | 神經(jīng)保護(hù)化合物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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