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Postion:Product Catalog >Biochemical Engineering>Plant extracts>Tanshinone IIA
Tanshinone IIA
  • Tanshinone IIA
  • Tanshinone IIA
  • Tanshinone IIA
  • Tanshinone IIA
  • Tanshinone IIA

Tanshinone IIA NEW

Price Get Latest Price
Package 25KG
Min. Order: 1KG
Supply Ability: 50000KG/month
Update Time: 2023-08-29

Product Details

Product Name: Tanshinone IIA CAS No.: 568-72-9
Min. Order: 1KG Purity: 99%
Supply Ability: 50000KG/month Release date: 2023/08/29

CAS:568-72-9
MF:C19H18O3
MW:294.34
EINECS:
Product Categories:Inhibitors;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Plant Oils, Toxins, Phenolic Acids & Derivatives;The group of Danshen;Plant extract
Mol File:568-72-9.mol
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Tanshinone IIA Chemical Properties
Melting point 196.0 to 200.0 °C
Boiling point 480.7±44.0 °C(Predicted)
density 1.209±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility methanol: soluble5mg/mL, clear, red-orange to red
form powder, red
color Orange
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKeyHYXITZLLTYIPOF-UHFFFAOYSA-N
LogP4.925 (est)
CAS DataBase Reference568-72-9(CAS DataBase Reference)
Tanshinone IIA Usage And Synthesis
DescriptionTanshinone IIA mainly exists in the roots of Salvia miltiorrhiza Bge. Traditional Chinese medicine Danshen, slightly cold and bitter, is often used for activating blood circulation and eliminating stasis in Chinese medicine. It can also promote blood circulation, open the energy channels, calm the heart, cool the blood, relieve swelling, remove twinge in the heart and stomach, and remove carbuncle and erysipelas. It is classified as high grade in Shen Nong’s Herbal Classic. It has been used as a traditional Chinese medicine in clinical practice for thousands of years. And it is not only recorded in the leading medical works through the ages but also in CP and USP.
DescriptionTanshinone IIA (TSA) is a major lipophilic component of extracts from the root of S. miltiorrhiza, used widely in Chinese herbal medicine. It has anti-inflammatory activity, inhibiting production of TNF-α, IL-1β, IL-6, NO, INFγ, and expression of iNOS, and IL-12. It blocks human aortic smooth muscle cell migration, inhibits MMP-9 activity, and interferes with PI3K/Akt and ERK1/2 signaling pathways. It is cytotoxic to various cancer cells including A549 lung cancer cells and leukemia cells.Reduction of TSA by NAD(P)H:quinone oxidoreductase (NQO1) generates an unstable intermediate resulting in reactive oxygenase species-mediated apoptotic cell death.
Chemical PropertiesOrange powder
Physical propertiesAppearance: brick-red crystalline powder. Melting point: 209–210?°C. Solubility: absorbs moisture easily, very soluble in hot water, slightly soluble in methanol or ethanol, and practically insoluble in chloroform
HistoryThe study of the chemical composition of Salvia miltiorrhiza began in the 1930s. Japanese scholars first extracted three kinds of liposoluble components from Danshen. They are tanshinones I, II, and III.
UsesTanshinone IIA is a derivative of Tanshinone and acts as a potential inhibitor of tumor growth in vivo. Also maintains vasodilating activity in vivo.
Usesantineoplastic, bone resorption inhibitor, antiproliferative, apoptosis inducer
DefinitionChEBI: 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g]benzofuran-10,11-dione is an abietane diterpenoid.
Synthesis Reference(s)Journal of the American Chemical Society, 111, p. 1522, 1989 DOI: 10.1021/ja00186a070
Biochem/physiol ActionsPhenanthrenequinone constituent of Chinese medicinal herb Danshen (Salvia miltiorrhiza). Anti-inflammatory. Antioxidant. Cytotoxic against a variety of cell lines, inlcuding human glioma cells.

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Packing &shipping&Payment

Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
Quantity(Kilograms)1 - 10000>10000
Est. Time(days)5To be negotiated

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Article illustrationCompany information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.

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