Tanshinone IIA sulfonate sodium NEW
| Price | $39 | $64 | $93 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-04 |
Product Details
| Product Name: Tanshinone IIA sulfonate sodium | CAS No.: 69659-80-9 |
| Purity: 99.04% | Supply Ability: 10g |
| Release date: 2024/11/04 |
Product Introduction
Bioactivity
| 名稱 | Tanshinone IIA sulfonate sodium |
| 描述 | Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor P2X7. Tanshinone IIA sulfonate sodium (12.5 μM) inhibits hypoxia-induced PKG and PPAR-γ downregulation in PASMCs and distal pulmonary arteries of rats. |
| 體外活性 | Sodium Tanshinone IIA sulfonate (12.5 μM) effectively inhibits hypoxia-induced downregulation of PKG and PPAR-γ in PASMCs and distal pulmonary arteries of rats, preserving pulmonary vascular function. It prevents TRPC1 and TRPC6 reduction in hypoxic PASMCs, reversible upon PKG or PPAR-γ knockdown, implicating the PKG-PPAR-γ axis in mitigating PASMCs' proliferative response under hypoxia. A PPAR-γ agonist enhances the compound's maintenance of basal calcium levels and store-operated calcium entry (SOCE) in PASMCs. Sodium Tanshinone IIA sulfonate dose-dependently inhibits CYP3A4 activity in human liver microsomes (HLMs) and the CYP3A4 isoform with minimal impact on other CYP enzymes, suggesting a specific interaction with the CYP3A4 pathway. Kinetic parameters for CYP3A4 inhibition are detailed for both HLMs and the CYP3A4 isoform. Due to its significant CYP3A4 inhibitory effect, it has potential for drug-drug interactions with other CYP3A4 substrates. |
| 體內(nèi)活性 | Sodium Tanshinone IIA sulfonate administered at dosages of 10 mg/kg and 20 mg/kg, in conjunction with Donepezil, effectively reduces escape latency, enhances the number of times subjects crossed the original platform location, and extends the duration spent in the target quadrant in experimental settings. This compound notably diminishes acetylcholinesterase (AChE) activity while boosting choline acetyltransferase (ChAT) activity within the hippocampus and cortex of SCOP-treated mice, alongside increasing superoxide dismutase (SOD) activity and reducing malondialdehyde (MDA) and reactive oxygen species (ROS) levels in the same regions. At a preventive dosage of 30 mg/kg/day, Sodium Tanshinone IIA sulfonate mitigates the characteristic alterations induced by hypoxia in a chronic hypoxia PH rat model. Moreover, when administered intraperitoneally at dosages of 20, 10, and 5 mg/kg, it effectively prevents peritoneal adhesion without impeding anastomotic healing in rats, demonstrating increased peritoneal lavage fluid tPA activity and tPA/PAI-1 ratio, alongside decreased TGF-β1 and collagen I expressions in ischemic tissues. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (126.14 mM), The compound is unstable in solution. Please use soon. |
| 關(guān)鍵字 | CRAC Channel | Calcium release-activated channels | Tanshinone IIA sulfonate sodium | Ca2+ release-activated Ca2+ channels | inhibit | Inhibitor |
| 相關(guān)產(chǎn)品 | Tebuconazole | Nisoldipine | L-Ascorbic acid | Apigenin | Lanthanum(III) chloride heptahydrate | Fenofibrate | Ethyl cinnamate | Naringin | Naringenin | 1-Octanol | Melatonin | Tauroursodeoxycholate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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