Syrosingopine NEW
| Price | $61 | $145 | $223 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-06 |
Product Details
| Product Name: Syrosingopine | CAS No.: 84-36-6 |
| Purity: 99.78% | Supply Ability: 10g |
| Release date: 2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | Syrosingopine |
| 描述 | Syrosingopine is a dual inhibitor of MCT1 and MCT4, 60 times more potent against MCT4, preventing lactate and H+ efflux. Syrosingopine is an orally available antihypertensive drug with potential for cancer research in combination with metformin. |
| 體外活性 | METHODS: Metformin, phenformin, and selected mitochondrial inhibitors were titrated in HL60 cells in the presence of a fixed concentration of syrosingopine (5 μM). RESULTS Metformin sensitivity was altered approximately 15-fold in the presence of syrosingopine and 13-fold in the presence of phenformin.[1] METHODS: MDA-MB-231 cells were treated with syrosingopine (1, 5, 10, 25, 50, 75, 10 μM) to evaluate the effects of syrosingopine treatment on the extracellular acidification rate (ECAR) and intracellular acidification in MDA-MB-231 cells. RESULTS The extracellular acidification rate (ECAR) was significantly reduced in cells. The reduction in ECAR was stable over time and did not differ between 24 or 72 h of exposure. For the more oxidative FaDu model, a significant reduction in ECAR was observed after treatment with 25 μM syrosingopine; the pHi values ??of MDA-MB-231 cells were 50 μM and the pHi values ??of FaDu were 25 μM. [2] |
| 體內(nèi)活性 | METHODS: Tsc1?/Pten? liver knockout mice were treated with syrosingopine (7.5 mg/kg, intraperitoneally), metformin (200 mg/kg), or the combination on alternate days for a total of 6 treatments. The in vivo efficacy of the drug combination was tested in a mouse liver cancer model. RESULTS After this short treatment, liver size and the number of visible tumor nodules were reduced; histological examination of liver sections showed a reduction in tumor burden. [1] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 62.5 mg/mL (93.74 mM), Sonication is recommended. |
| 關(guān)鍵字 | cancer | NAD+ | Su-3118 | MCTs | Su 3118 | synthetic lethality | inhibit | metformin | lactate | Syrosingopine | glycolysis | Su3118 | Monocarboxylate Transporter | Inhibitor |
| 相關(guān)產(chǎn)品 | Olanzapine | CLOZAPINE N-OXIDE | Mirtazapine | Octopamine hydrochloride | L-DOPA | Octodrine | Citicoline | Phenothiazine | Oxolinic acid | Mianserin hydrochloride | Doxepin hydrochloride | Fluphenazine dihydrochloride |
| 相關(guān)庫(kù) | 抗癌天然產(chǎn)物庫(kù) | 中藥單體化合物庫(kù) | 神經(jīng)退行性疾病化合物庫(kù) | 生物堿類天然產(chǎn)物庫(kù) | 植物來(lái)源化合物庫(kù) | 天然產(chǎn)物庫(kù) | 抑制劑庫(kù) | 高通量篩選天然產(chǎn)物庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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