• MOLECULAR FORMULA :

• C16-H10-N2-O7-S2.2Na

• MOLECULAR WEIGHT :

• 452.38

• WISWESSER LINE NOTATION :

• L66J BNUNR DSWQ& CQ HSWQ &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• >10 gm/kg

• TOXIC EFFECTS :

• Gastrointestinal - hypermotility, diarrhea

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 3800 mg/kg

• TOXIC EFFECTS :

• Behavioral - convulsions or effect on seizure threshold Behavioral - coma Gastrointestinal - hypermotility, diarrhea

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• >6 gm/kg

• TOXIC EFFECTS :

• Gastrointestinal - hypermotility, diarrhea

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 4600 mg/kg

• TOXIC EFFECTS :

• Behavioral - convulsions or effect on seizure threshold Behavioral - coma Gastrointestinal - hypermotility, diarrhea

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 243 gm/kg/96D-C

• TOXIC EFFECTS :

• Gastrointestinal - other changes Related to Chronic Data - changes in testicular weight

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 476 mg/kg/28D-C

• TOXIC EFFECTS :

• Blood - changes in leukocyte (WBC) count

MUTATION DATA

• TYPE OF TEST :

• Cytogenetic analysis

• TEST SYSTEM :

• Rodent - hamster Lung

• DOSE/DURATION :

• 2 gm/L

• REFERENCE :

• GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,257,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,257,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 14,127,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2135 No. of Facilities: 2510 (estimated) No. of Industries: 14 No. of Occupations: 21 No. of Employees: 17624 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2135 No. of Facilities: 11207 (estimated) No. of Industries: 67 No. of Occupations: 62 No. of Employees: 195835 (estimated) No. of Female Employees: 103566 (estimated)