Sumatriptan succinate NEW
| Price | $35 | $51 | $153 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-04 |
Product Details
| Product Name: Sumatriptan succinate | CAS No.: 103628-48-4 |
| Purity: 99.51% | Supply Ability: 10g |
| Release date: 2024/11/04 |
Product Introduction
Bioactivity
| 名稱 | Sumatriptan succinate |
| 描述 | Sumatriptan succinate (GR 43175), a serotonin1 (5-HT1) receptor agonist, is used in the acute treatment of a migraine headache. |
| 體外活性 | Sumatriptan is rapidly cleared through metabolism and renal elimination, with a half-life of 1-2 hours. It rarely produces adverse effects when administered acutely, except for dogs exhibiting low tolerance to high doses. Clinically, subcutaneous injection of Sumatriptan at 100 mg/kg notably decreases injury-induced and contralateral mechanical allodynia in a rat model of trigeminal neuropathic pain (peak effects at 6.3g and 4.4g, respectively). In cats, Sumatriptan reduces the number of Fos-positive cells in the caudal part of the spinal trigeminal nucleus (I, IIO, and C2) following mechanical stimulation (to 6, 13, and 9 cells, respectively). The compound's biological activity varies across species, with 37%, 23%, and 58% in rats, rabbits, and dogs, respectively. Sumatriptan selectively constricts cranial blood vessels, which are dilated and inflamed during migraines, mediated by the 5-HT1 receptor subtype in animal cranial vasculature. |
| 體內(nèi)活性 | Sumatriptan significantly reduces plasma protein-induced extravasation triggered by electrical stimulation of the trigeminal nerve. It mitigates morphological changes in the capillaries within the dura mater and small veins in the presence of hypertrophied mast cells stimulated at the trigeminal ganglion. Sumatriptan has a slightly lower affinity for the serotonin receptor 1A binding site (KI=100 nM), while exhibiting the highest affinity for 5HT (Ki=17 nM) and 5HT1B receptor binding sites (Ki=27 nM). |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 55 mg/mL (133.01 mM) H2O : 41.4 mg/mL (100 mM) |
| 關(guān)鍵字 | Inhibitor | 5-hydroxytryptamine Receptor | inhibit | migraine headache | 5-HT1B | GR-43175 | Sumatriptan succinate | Sumatriptan Succinate | orally active | Sumatriptan | Serotonin Receptor | 5-HT Receptor | GR43175 | 5-HT1D | antimigraine activity |
| 相關(guān)產(chǎn)品 | Alverine citrate | Olanzapine | Dapoxetine hydrochloride | CLOZAPINE N-OXIDE | Amitriptyline hydrochloride | Cloperastine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Fluoxetine hydrochloride | Cinchonidine |
| 相關(guān)庫 | 神經(jīng)退行性疾病化合物庫 | 經(jīng)典已知活性庫 | 疼痛相關(guān)化合物庫 | 膜蛋白靶向化合物庫 | 藥物功能重定位化合物庫 | 抗癌上市藥物庫 | FDA 上市藥物庫 | 已知活性化合物庫 | GPCR靶點分子庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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