Sulindac sulfide NEW
| Price | $31 | $48 | Get Latest Price |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-06 |
Product Details
| Product Name: Sulindac sulfide | CAS No.: 49627-27-2 |
| Purity: 99.68% | Supply Ability: 10g |
| Release date: 2024/11/06 |
Product Introduction
Bioactivity
| 名稱(chēng) | Sulindac sulfide |
| 描述 | Sulindac sulfide (cis-Sulindac sulfide) is a non-steroidal anti-inflammatory compound that has a high affinity for COX-1 and acts as an inhibitor in Ras activation of Raf-1. Sulindac sulfide is a non-competitive inhibitor of gamma-secretase with an IC50 value of 20.2 μM. It is an active metabolite of sulinic acid. |
| 體外活性 | Treatment with 100 μM of Sulindac sulfide (SSide) induces apoptosis leading to significant reduction in Aβ generation and total protein expression. The IC50 for Aβ42 secretion of SSide is 30.6±2.8 μM. SSide inhibits γ42-secretase activity dose-dependently, with an IC50 of 20.2±2.6 μM. Increasing SSide concentration decreases the slope in the rate vs. enzyme concentration plot, indicating SSide is not an irreversible or pseudo-irreversible inhibitor. After pretreatment of the dialyzed solubilized γ-secretase fraction with SSide and subsequent exposure to CHAPSO buffer without SSide, γ-secretase activity almost fully recovers. This strongly suggests that SSide targets the γ-secretase complex as a reversible inhibitor. [1] |
| 體內(nèi)活性 | Sulindac sulfide also inhibits aldose reductase, blocking NADPH-dependent reduction of glucose to sorbitol, and reducing type 2 diabetic complications.[2] Sulindac sulfide inhibits colorectal cancer growth both in vitro and in vivo.[5] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 45 mg/mL (132.19 mM), Sonication is recommended. |
| 關(guān)鍵字 | Sulindac sulfide | cis-Sulindac Sulfide | Sulindac Sulfide |
| 相關(guān)產(chǎn)品 | Adiphenine hydrochloride | Nanofin | Arecoline hydrobromide | Forskolin | Ribavirin | Sorafenib | Adenine | Regorafenib | Choline chloride | Propoxur |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 疼痛相關(guān)化合物庫(kù) | 神經(jīng)信號(hào)分子庫(kù) | 膜蛋白靶向化合物庫(kù) | 激酶抑制劑庫(kù) | 抗肥胖化合物庫(kù) | 神經(jīng)遞質(zhì)受體化合物庫(kù) | 抑制劑庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $0.00/1g |
VIP1Y
|
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
|
2024-09-29 | |
| $47.00/100mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-09 | |
| $0.00/50mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-06 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY