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Postion:Product Catalog >Sugammadex sodium
Sugammadex sodium
  • Sugammadex sodium

Sugammadex sodium NEW

Price $34 $54 $86
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Sugammadex sodium CAS No.: 343306-79-6
Purity: 99.44% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameSugammadex sodium
DescriptionSugammadex sodium (Org25969) , a synthetic derivative of γ-cyclodextrin, is a steroid-based neuromuscular blocker reversing agent.
Animal ResearchThe animals were anesthetized with 80 mg/kg ketamine hydrochloride and 12 mg/kg xylazine administered intraperitoneally. After the rats were anesthetized, the bilateral common carotid arteries were exposed and carefully separated from the carotid sheath and the cervical sympathetic and vagal nerves through a ventral cervical incision. The bilateral common carotid arteries were occluded with nontraumatic aneurysm clips in ischemic rats but were not clamped in sham-operated rats. Complete interruption of the blood flow was confirmed by observing the central artery in the retina with an ophthalmoscope. The body temperature of the rats was maintained at 37.0 ± 0.5°C during this procedure. In this model, 10 minutes of ischemia and 24 hours of reperfusion were induced. After the ischemic period, the rats were treated with sugammadex 16 mg/kg (S 16 group) and sugammadex 100 mg/kg (S 100 group) (intravenous and total volume 1 mL) in the 5th minute of reperfusion. Sugammadex was diluted with normal saline (0.9% NaCl). The same surgical procedure was performed in the I/R group, but the rats were not treated with sugammadex. The neck incision was closed with sutures (3.0 silk), and the animals were allowed to awaken. After 24 hours, the neurological condition of the rats was assessed with a scoring system [2].
In vivoInjection of 100 microg/kg rocuronium resulted in a mean neuromuscular blockade of 93.0%, and profound blockade was achieved by injection of 500 microg/kg. After injection of the high rocuronium dose, the 90% recovery of the train-of-four ratio took 28 min after saline, 26 min after 1 mg/kg sugammadex, and 8 min after 2.5 mg/kg sugammadex. Signs of residual blockade or recurarization were not observed [1]. Treatment with 16 mg/kg and 100 mg/kg sugammadex had a neuroprotective effect in a transient global cerebral I/R rat model. However, 100 mg/kg sugammadex was more neuroprotective in rats [2].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationH2O : 34 mg/mL (15.61 mM)
Keywordsinhibit | Inhibitor | anesthesia | Sugammadex | Org 25969 | reversal agent | neuromuscular block | Sugammadex sodium | ischemic | Org-25969 | Neuroprotective
Related Compound LibrariesMacrocyclic Compound Library | NO PAINS Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
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