STING-IN-5 NEW
| Price | $1370 | $2780 | $3700 |
| Package | 5mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: STING-IN-5 | CAS No.: 2920064-17-9 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | STING-IN-5 |
| Description | STING-IN-5, a potent inhibitor of the Stimulator of Interferon Genes (STING) pathway, significantly suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO) synthesis in macrophages, exhibiting an IC50 of 1.15 μM. This compound dampens the inflammatory response and offers potential for research into anti-inflammatory diseases and sepsis [1]. |
| In vitro | STING-IN-5 (compound 30) (40 μM; 24 h) exerts minimal impact on the viability of RAW264.7 cells [1]. At concentrations of 2.5 and 5 μM for 2 hours, STING-IN-5 inhibits nitric oxide (NO) production in LPS-stimulated RAW264.7 cells, with inhibition rates of 69.28 ± 2.36% and 78.66 ± 2.73% respectively, and an IC 50 of 1.15 ± 0.15 μM [1]. Furthermore, STING-IN-5 (0.5-2 μM; 2 h) suppresses STING activation and subsequent TBK1/IRF3/NF-κB signaling [1]. |
| In vivo | STING-IN-5, administered orally at doses ranging from 1.25 to 5 mg/kg once daily for three consecutive days, showed significant protective effects against acute hepatic injury in mice with sepsis [1]. The pharmacokinetic parameters of STING-IN-5 in male Sprague-Dawley rats include a peak concentration time (Tmax) of 1 hour, a maximum concentration (Cmax) of 66.52 ng/mL, an area under the curve from time zero to the last quantifiable concentration (AUC0-t) of 81.08 ng/mL·h, an area under the curve from time zero to infinity (AUC0-∞) of 135.7 ng/mL·h, a half-life (T1/2) of 1.11 hours, a mean residence time from time zero to the last quantifiable concentration (MRT0-t) of 0.99 hours, and a mean residence time from time zero to infinity (MRT0-∞) of 2.02 hours [1]. |
| Storage | Shipping with blue ice. |
| Inhibitors Related | SR-717 | ChX710 | SN-008 | Vadimezan | Dazostinag disodium | C-176 | Cridanimod | CCCP | diABZI STING agonist-1 trihydrochloride | MSA-2 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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