Product Details
| Product Name:
SRI-37240 |
CAS No.:
883956-47-6 |
| Purity:
98.73% |
Supply Ability:
10g |
| Release date:
2024/11/12 |
Product Introduction
Bioactivity
| 名稱 | SRI-37240 |
| 描述 | SRI-37240 is a potent inhibitor of premature termination codons (PTCs) with read-across activity that induces a prolonged pause at the termination codon and inhibits PTCs associated with cystic fibrosis.SRI-37240 can be used to study PTC-related diseases. |
| 體外活性 | SRI-37240 (1, 3, 10, and 30 μM; 48 h) enhances CFTR-dependent chloride conductance in a concentration-dependent manner, activated by Forskolin and inhibited by CFTR Inh-172 [1]. At 10 μM over 72 h, it significantly increases levels of both mature, fully glycosylated and immature CFTR protein forms in 16HBEge cells, especially when used with G418 (100 μM) [1]. Additionally, at 10 μM for 24 h, SRI-37240 alters cellular translation termination at premature termination codons (PTCs) in HEK293T cells, boosts ribosome densities at normal stop codons, and does not affect ribosome densities in 3'-UTRs [1]. The compound also restores CFTR function in primary bronchial epithelial cells with G418 treatment over 72 h [1]. Western Blot Analysis shows a significant increase in both mature (Band C) and immature (Band B) CFTR protein forms at 10 μM for 24 h in CFTR-G542X 16HBEge cells with G418 (100 μM) [1]. |
| 存儲條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 5 mg/mL (12.97 mM), Sonication is recommended.
|
| 相關(guān)產(chǎn)品 | Glibenclamide | CFTR corrector 8 | Lumacaftor | VRT-532 | GLPG1837 | Glucosamine | Ataluren | DNDS | BPO-27 racemate | Ivacaftor |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1520.00/25mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-28 |
|
|
$52.00/2mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-10-23 |
United States