Spiramycin NEW
| Price | $40 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-06 |
Product Details
| Product Name: Spiramycin | CAS No.: 8025-81-8 |
| Purity: 97.92% | Supply Ability: 10g |
| Release date: 2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | Spiramycin |
| 描述 | Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens, effective against gram-positive aerobic pathogens, N. gonorrhoeae, and staphylococci, and is used to treat infections caused by bacteria and Toxoplasma gondii. |
| 體內(nèi)活性 | Spiramycin acts by binding to the bacterial 50S ribosomal subunit, thereby inhibiting translocation. Its primary mechanism during translocation involves stimulating the dissociation of peptidyl-tRNA from the ribosome. The compound reduces the protective effect of anisomycin on 23S rRNA nucleotides. Spiramycin exhibits potent antibacterial activity against the genus Prevotella, Streptococcus mitis, Archaea, strains of Porphyromonas, and Bacteroides, with metronidazole enhancing its efficacy. At 30°C, Spiramycin can inhibit protein synthesis in wild-type cells but not kill mutant or wild-type cells. Treating lipopolysaccharide-stimulated human monocytes with Spiramycin and erythromycin increases the total production of IL-6 without affecting TNFα, IL-1α, or IL-1β production. Spiramycin inhibits protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes. It dose-dependently inhibits the proliferative response of human mononuclear cells stimulated by pulse-width modulation and polyhydroxyalkanoate esters. Additionally, Spiramycin induces a reduction in tritiated thymidine uptake, suggesting interference with an early stage of the cell cycle. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 93 mg/mL (110.3 mM) Ethanol : 93 mg/mL (110.3 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) |
| 關(guān)鍵字 | Antibiotic | inhibit | Inhibitor | Bacterial | Parasite | Spiramycin |
| 相關(guān)庫 | 抗癌天然產(chǎn)物庫 | 抗寄生蟲庫 | 經(jīng)典已知活性庫 | 藥物功能重定位化合物庫 | 糖類及苷類化合物庫 | 微生物天然產(chǎn)物庫 | 高通量篩選天然產(chǎn)物庫 | 抗感染天然產(chǎn)物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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