Product Details
| Product Name:
sphondin |
CAS No.:
483-66-9 |
| Purity:
≥95% |
Supply Ability:
10g |
| Release date:
2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | sphondin |
| 描述 | Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells. |
| 體外活性 | Sphondin inhibits IL-1beta-induced PGE(2) release in A549 cells;?this inhibition is mediated by suppressing of COX-2 expression, rather than by inhibiting COX-2 enzyme activity.?The inhibitory mechanism of sphondin on IL-1beta-induced COX-2 expression may be, at least in part, through suppression of NF-kappaB activity. Sphondin may have the therapeutic potential as an anti-inflammatory drug on airway inflammation[1]. |
| 體內(nèi)活性 | Sphondin, showed anti-proliferative activity and caused G2/M arrest at concentrations of 0.05-15.0 Μm[2]. |
| 存儲(chǔ)條件 | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 30 mg/mL (138.77 mM)
|
| 關(guān)鍵字 | COX | airway | anti-inflammatory | epithelial | Cyclooxygenase | pulmonary | inflammation | inhibit | PGE2 | A549 | Inhibitor | COX-2 | sphondin |
| 相關(guān)產(chǎn)品 | Bismuth Subsalicylate | Ibuprofen | Acetaminophen | Salicylamide | Diclofenac sodium | Diclofenac Potassium | trans-Cinnamaldehyde | Paradol | Indomethacin sodium hydrate | Salicylic acid | Glafenine | Revaprazan hydrochloride |
| 相關(guān)庫(kù) | 抗癌天然產(chǎn)物庫(kù) | 中藥單體化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 中藥抗炎分子庫(kù) | 天然產(chǎn)物庫(kù) | 抑制劑庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 古代經(jīng)典名方目錄分子庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$0.00/1g |
VIP5Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2020-01-06 |
United States