Description:

Chemical Structure and Properties:

Chemical Formula: C10H26N4

Molecular Weight: 202.34 g/mol

Chemical Name: N,N'-bis(3-aminopropyl)butane-1,4-diamine

Sources:

Spermine is a polyamine that is found in all eukaryotic cells. It is present in a variety of tissues and is particularly abundant in the reproductive system, including seminal fluid.

It is also found in certain foods, such as meat, fish, and some vegetables.

Mechanism of Action

Spermine interacts with various cellular components and processes, including:

DNA Stabilization: Spermine binds to DNA, helping to stabilize its structure. This is particularly important in the packaging of DNA within the cell nucleus.

Cell Growth and Proliferation: Spermine is involved in the regulation of cell growth and differentiation. It plays a role in cell cycle progression and apoptosis (programmed cell death).

Antioxidant Properties: Spermine has been shown to have antioxidant properties, protecting cells from oxidative stress and damage.

Uses and Applications

Biological Research:

Cell Culture: Spermine is often used in cell culture media to support the growth and maintenance of cells.

DNA Research: Due to its ability to stabilize DNA, spermine is used in various molecular biology applications, including DNA extraction and purification.

Medical Research:

Cancer Research: Spermine levels are often elevated in cancer cells. Studying spermine metabolism and its role in cancer can provide insights into potential therapeutic targets.

Neuroprotection: Spermine has neuroprotective effects and is being studied for its potential role in treating neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

Agriculture:

Plant Growth: Spermine is used in agricultural research to study its effects on plant growth and development. It can influence processes such as seed germination, root development, and stress responses.

Safety and Side Effects

Safety: Spermine is naturally occurring in the body and is generally considered safe at physiological levels. However, excessive levels of polyamines, including spermine, have been associated with certain pathological conditions, such as cancer.

Side Effects: There are no well-documented side effects of spermine at physiological levels. However, as with any compound, it is important to use it appropriately and consult with a healthcare provider or a research supervisor when using it in experimental settings.

Conclusion

Spermine is a crucial polyamine involved in a variety of cellular processes, including DNA stabilization, cell growth, and antioxidant defense. Its roles in biological and medical research are significant, providing insights into cell biology, cancer research, and neuroprotection. While it is generally considered safe at physiological levels, it is important to understand its functions and potential implications in various contexts.

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Shipping ways: Courier, Air, Sea, Road

Storage Condition: Dry, dark, and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).