Sodium 4-aminosalicylate dihydrate NEW
| Price | $29 |
| Package | 5g |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Sodium 4-aminosalicylate dihydrate | CAS No.: 6018-19-5 |
| Purity: 99.78% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Sodium 4-aminosalicylate dihydrate |
| Description | Sodium 4-aminosalicylate dihydrate (4-Amino-salicylic acid sodium salt) is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA) with antitubercular activity. Sodium 4-aminosalicylate dihydrate exerts its bacteriostatic activity against Mycobacterium tuberculosis by competing with PABA for enzymes involved in folate synthesis, thereby suppressing growth and reproduction of M. tuberculosis, eventually leading to cell death. |
| In vitro | Following local perfusion with 7.5 mg/mL of 4-aminosalicylate, N-acetyl-5-aminosalicylic acid was detected in the intestines of anesthetized rats. |
| In vivo | 4-Aminosalicylate exhibits effective DPPH radical scavenging activity and rapidly neutralizes hydroperoxyl radicals in aqueous solutions, displaying a concentration-dependent cycle similar to that of Trolox or cysteine, indicative of chain-breaking antioxidant activity. At 0.65 mM, 4-aminosalicylate attenuates the lethal effects of superoxide radicals or hydrogen peroxide on Chinese hamster ovary cells. In cultured mouse peritoneal macrophages, aminosalicylate (25 mM) stimulates phospholipase D in a time- and concentration-dependent manner, and at 5 mM, it enhances protein kinase C activation of PLD. Post-treatment with 4-aminosalicylate (20 mM) results in a 260% increase in inositol 1,4,5-trisphosphate levels in macrophages. Furthermore, in isolated colonic mucosal cells, 4-aminosalicylate (0.1 mM) dose-dependently reduces the synthesis of LTB4, thereby decreasing the LTB4/PGE2 ratio. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 198.9 mM DMSO : 55 mg/mL (260.48 mM) |
| Keywords | 4-Aminosalicylic acid sodium salt dihydrate | 4-Amino-salicylic acid sodium | Sodium 4-aminosalicylate Dihydrate | Sodium 4-aminosalicylate | Inhibitor | inhibit | Bacterial | Antibiotic | Sodium 4 aminosalicylate dihydrate | Sodium 4aminosalicylate dihydrate | Sodium 4-aminosalicylate dihydrate |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Kanamycin sulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | EDTA copper(II) disodium salt | Dimethyl sulfoxide | Diallyl disulfide | Crystal Violet |
| Related Compound Libraries | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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