Product Details
Product Name:
SNDX-5613 |
CAS No.:
2169919-21-3 |
Purity:
99.12% |
Supply Ability:
10g |
Release date:
2024/11/18 |
Product Introduction
Bioactivity
名稱 | SNDX-5613 |
描述 | Revumenib (SNDX-5613) is a potent and selective oral inhibitor of menin-KMT2A interaction with Ki of 0.149 nM and IC50 between 10 and 20 nM, which can be used in the study of acute leukemia with MLL gene rearrangement. |
體外活性 | METHODS: Primary patient-derived NUP98-r AML cells were treated with Revumenib (SNDX-5613) (2, 46, 125 nM) and cell viability was measured.
RESULTS Revumenib inhibited the growth of primary patient-derived NUP98-r AML cells. [3] |
體內(nèi)活性 | SNDX-5613 treatment provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts.SNDX-5613 shows in vivo plasma( IC50 : 53 nM) . |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 60 mg/mL (95.11 mM), Sonication is recommended.
|
關(guān)鍵字 | acute | SNDX 5613 | SNDX5613 | Leukemia | inhibit | lymphoblastic | Epigenetic Reader Domain | Inhibitor | AML | Menin | ALL | SNDX-5613 | MLL | myeloid |
相關(guān)產(chǎn)品 | ABBV-744 | 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one | (+)-JQ-1 | Tazemetostat | Piribedil | GSK126 | Curcumin | EPZ015666 | dBET6 | Naphthol AS-E | MRTX-1719 | Bisdemethoxycurcumin |
相關(guān)庫 | 細(xì)胞重編程化合物庫 | 經(jīng)典已知活性庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | PPI抑制劑庫 | 已知活性化合物庫 | 抗癌化合物庫 | 抗癌藥物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
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Suppliers |
Update time |
|
$67.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-18 |
|
$1.00/150box |
VIP4Y
|
Wuhan Nutra Biotechnology Co.,Ltd
|
2022-11-19 |