SLIGRL-NH2 TFA NEW
| Price | Get Latest Price | |
| Package | 5mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: SLIGRL-NH2 TFA | CAS No.: 2828432-39-7 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | SLIGRL-NH2 TFA |
| Description | SLIGRL-NH2 TFA, also known as Protease-Activated Receptor-2 Activating Peptide TFA, is a Protease-Activated Receptor-2 (PAR-2) agonist [1]. |
| In vitro | SLIGRL-NH2 serves as an agonist for both PAR-2 and MrgprC11 [1]. It induces a relaxation that is inhibited by L-NAME, suggesting a nitric oxide-dependent mechanism. Importantly, SLIGRL-NH2 achieves a concentration-dependent relaxation with an EC50 of 10 μM in endothelium-free preparations when accompanied by perivascular adipose tissue (PVAT). Consequently, a concentration of 20 μM is selected for further experiments to assess the influence of inhibitors on ADRF release and activity. In endothelium-denuded aortic preparations, the peptide solely elicits this concentration-dependent relaxation in conjunction with PVAT [+PVAT, -ENDO (endothelium)] [2]. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
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TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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