Product Details
| Product Name:
Sirpiglenastat |
CAS No.:
2079939-05-0 |
| Purity:
98.01% |
Supply Ability:
10g |
| Release date:
2024/11/11 |
Product Introduction
Bioactivity
| 名稱 | Sirpiglenastat |
| 描述 | Sirpiglenastat (DRP-104), a glutamine antagonist and prodrug of DON, exhibits antitumor activity by inhibiting glutamine metabolism and stimulating both the innate and adaptive immune systems. |
| 體外活性 | Treatment with Sirpiglenastat (DRP-104) exhibits broad immune cell modulation effects, including an increase in T cells, NK cells, and macrophages. Sirpiglenastat also reduces the levels of pro-tumorigenic cytokines such as VEGF and KC (IL-8)[1]. |
| 體內(nèi)活性 | In CT26 bearing mice, treatment with Sirpiglenastat (DRP-104) at a dose of 0.5 mg/kg through subcutaneous injection once a day for 5 days results in a 90% inhibition of tumor growth by day 12, with a median survival of 36 days[1].Additionally, Sirpiglenastat treatment (0.5 mg/kg; s.c) significantly inhibits tumor growth in the H22 model[1]. |
| 存儲(chǔ)條件 | keep away from direct sunlight,keep away from moisture | Shipping with blue ice. |
| 溶解度 | DMSO : 80 mg/mL (181.21 mM), Sonication is recommended.
|
| 相關(guān)產(chǎn)品 | GLS1 Inhibitor-4 | Glutaminase C-IN-1 | BJJF078 | L-Albizziin | ZED-1227 | GK921 | GLS1 Inhibitor-7 | Glutaminase-IN-3 | 6-Diazo-5-oxo-L-nor-Leucine | Telaglenastat | UPGL00004 | BPTES |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 藥物功能重定位化合物庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States