Product Details
| Product Name:
SF2523 |
CAS No.:
1174428-47-7 |
| Purity:
98.06% |
Supply Ability:
10g |
| Release date:
2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | SF2523 |
| 描述 | SF2523 is a highly selective and potent inhibitor (SF2523) with improved physicochemical properties, excellent aqueous solubility, and biological efficacy. It is typically used in genome editing [CRISPR/Cas Solution] technology and can effectively enhance the efficiency of this process. |
| 體外活性 | Treatment with SF2523 leads to a reduction in the protein levels of MYCN and Cyclin D1, targets of MYCN. It also impedes AKT activation by preventing the phosphorylation at Ser473 and results in the removal of BRD4 from MYCN promoter sites. SF2523 exhibits a strong interaction with full-length BRD4 (Kd=140 nM), showing a similar affinity for BRD4's first bromodomain (BD1) (Kd=150 nM) but a weaker affinity for its second bromodomain (BD2) (Kd=710 nM). When comparing the binding affinities of SF2523 to bromodomains (BDs) of different proteins, it demonstrates equal binding to BDs of BRD4, BRD2, and BRD3; a moderate binding to BDs of CECR2 and BRDT; and significantly weaker binding to other BDs[1]. |
| 體內(nèi)活性 | Treatment with SF2523 significantly reduces tumor volume without causing gross toxicity in mice, as evidenced by stable body weight. Furthermore, tumors in mice treated with SF2523 exhibit notably lower levels of MYCN, pAKT, and Cyclin D1 compared to those in mice treated with the vehicle[1]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 10 mg/mL (26.92 mM)
|
| 關(guān)鍵字 | SF 2523 | SF-2523 | Inhibitor | PI3K | Phosphoinositide 3-kinase | Epigenetic Reader Domain | DNA-dependent protein kinase | DNA-PK | inhibit | SF2523 |
| 相關(guān)產(chǎn)品 | L-Leucine | 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one | (+)-JQ-1 | Myricetin | Erucic acid | Curcumin | Isoprenaline hydrochloride | Naphthol AS-E | Quercetin | Quercetin Dihydrate | Rapamycin | Apilimod |
| 相關(guān)庫(kù) | 抗肺癌化合物庫(kù) | 糖代謝化合物庫(kù) | 經(jīng)典已知活性庫(kù) | HIF-1化合物庫(kù) | 激酶抑制劑庫(kù) | 抗卵巢癌化合物庫(kù) | 抑制劑庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 抗癌活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States