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Postion:Product Catalog >Setmelanotide Acetate(920014-72-8 free base)
Setmelanotide Acetate(920014-72-8 free base)
  • Setmelanotide Acetate(920014-72-8 free base)

Setmelanotide Acetate(920014-72-8 free base) NEW

Price $133 $302 $453
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Setmelanotide Acetate(920014-72-8 free base) CAS No.: 2759937-80-7
Purity: 100% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameSetmelanotide Acetate(920014-72-8 free base)
DescriptionSetmelanotide Acetate(920014-72-8 free base) (RM-493 Acetate) is a selective agonist of melanocortin 4 receptor (MC4R)(human and rat MC4R with EC50s of 0.27 nM and 0.28 nM, respectively).
In vitroMelanocortin receptor agonists act in the brain to regulate food intake and body weight and, independently of these actions, affect insulin sensitivity. Setmelanotide exhibits agonist activity to human and rat MC4R(human and rat MC4R with Kis of 2.1 and 2.7 nM and EC50s of 0.27 and 0.28 nM, respectively)[1].
In vivoInhibition of refeeding after an overnight fast by BIM-22493 is dependent on functional MC4R.glucose homeostasis acutely improved by BIM-22493. BIM-22493(Lepob/Lepob mice) exhibits significantly improved glucose clearance when compared to controls. Chronic BIM-22493 treatment was associated with significantly lower levels of serum insulin, glucose and HOMA-IR values, suggesting an improvement in insulin sensitivity[1]. Treatment with setmelanotide results in transient decreases in food intake (35%), with persistent weight loss over 8 weeks of treatment (13.5%) in a diet-induced obese nonhuman primate model[2].
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 22.5 mg/mL (19.11 mM)
KeywordsRM 493 Acetate | Setmelanotide Acetate(920014728 free base) | BIM 22493 Acetate | RM493 Acetate | Setmelanotide Acetate(920014-72-8 free base) | BIM22493 Acetate | Setmelanotide Acetate(920014 72 8 free base) | IRC022493 Acetate | IRC 022493 Acetate
Inhibitors RelatedHS 014 acetate(207678-81-7 free base) | MCL0020 | Beta-MSH (1-22) (human) acetate | Neuropeptide EI, rat acetate | [D-Trp8]-γ-MSH acetate(321351-81-9 free base) | Undecylenoyl phenylalanine | ACTH 11-24 acetate(4237-93-8 free base) | Bremelanotide Acetate | HS024 | Nonapeptide-1 acetate salt (158563-45-2 free base)
Related Compound LibrariesBioactive Compound Library | Cyclic Peptide Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Peptide Compound Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | GPCR Compound Library | Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

Recommended supplier

Product name Price   Suppliers Update time
$173.00/1mg
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TargetMol Chemicals Inc.
2024-11-16
$0.00/1kg
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Zison Pharmaceutical (Shandong) Co., Ltd.
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$75.00/1kg
VIP2Y
Zibo Hangyu Biotechnology Development Co., Ltd
2023-11-30
$133.00/1mg
VIP3Y
TargetMol Chemicals Inc.
2024-11-19
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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