Product Details
| Product Name:
Scoulerine |
CAS No.:
6451-73-6 |
| Purity:
99.22% |
Supply Ability:
10g |
| Release date:
2024/11/18 |
Product Introduction
Bioactivity
| Name | Scoulerine |
| Description | Scoulerine is an inhibitor of ?-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells. |
| In vitro | Forty-six isoquinoline alkaloids, of eleven structural types isolated in our laboratory, have been evaluated for their cytotoxicity against two cancer cell lines (Caco-2 and Hep-G2 cancer cells), as well as against normal human lung fibroblast cells. Only Scoulerine, aromoline, berbamine and parfumidine showed significant cytotoxic effects, but only Scoulerine was active against both Caco-2 and Hep-G2 cells (IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively). Unfortunately, except for parfumidine, the other active alkaloids were also cytotoxic to the normal human lung fibroblast cells[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | proliferation | Inhibitor | cancer | Beta-secretase | Apoptosis | inhibit | microtubule | cycle | β-Secretase | Microtubule/Tubulin | leukemic | BACE | Scoulerine | cells | division | mitotic | Discretamine |
| Related Compound Libraries | 抗癌天然產(chǎn)物庫 | 經(jīng)典已知活性庫 | 中藥單體化合物庫 | 稀有天然產(chǎn)物庫 | 生物堿類天然產(chǎn)物庫 | 植物來源化合物庫 | 高通量篩選天然產(chǎn)物庫 | 抗感染天然產(chǎn)物庫 | 已知活性化合物庫 | 古代經(jīng)典名方目錄分子庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1.00/1KG |
VIP5Y
|
Career Henan Chemical Co
|
2020-01-03 |
United States