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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Nuclear transcription factor (NF-κB)>IκB / IKK inhibitors>SC-514
SC-514
  • SC-514

SC-514 NEW

Price $30 $48 $79
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-17

Product Details

Product Name: SC-514 CAS No.: 354812-17-2
Purity: 99.88% Supply Ability: 10g
Release date: 2024/11/17

Product Introduction

Bioactivity

名稱SC-514
描述SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
體外活性In nude mice implanted with A375 or G361 tumors, daily treatment was administered with SC-514 (25 mg/kg).
體內(nèi)活性In rheumatoid arthritis synovial fibroblasts (RASFs), SC-514 (100 μM) inhibits the phosphorylation and degradation of IκBα, while also preventing the translocation of p65 into the nucleus. In the presence of IL-1β-induced inflammation, SC-514 effectively suppresses the expression of NF-κB-dependent genes: IL-6 (IC50=20 μM), IL-8 (IC50=20 μM), and COX-2 (IC50=8 μM).
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 40 mg/mL (178.33 mM), Sonication is recommended.
Ethanol : 2.2 mg/mL (10 mM)
關(guān)鍵字IKK | I kappa B kinase | GK01140 | SC514 | SC-514 | GK-01140 | SC 514 | IκB kinase | Inhibitor | inhibit
相關(guān)產(chǎn)品Ribociclib | Amlexanox | AEBSF hydrochloride | Resveratrol | Bakuchiol | SB 202190 | (-)-Bornyl acetate | CASIN | Palbociclib | Sodium Oxamate | Abemaciclib | Benzamidine hydrochloride
相關(guān)庫(kù)高選擇性抑制劑庫(kù) | 細(xì)胞凋亡化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 疼痛相關(guān)化合物庫(kù) | 癌細(xì)胞分化化合物庫(kù) | 激酶抑制劑庫(kù) | 抑制劑庫(kù) | NO PAINS 化合物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù)

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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