Product Details
| Product Name:
SB756050 |
CAS No.:
447410-57-3 |
| Purity:
98.78% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | SB756050 |
| Description | SB756050 is a specific TGR5 agonist. |
| In vitro | TGR5 is a potential target for the therapy of type 2 diabetes (T2D). Thus, SB756050 is used in phase 1clinical trials for the treatment of type 2 diabetes. |
| In vivo | SB756050 is well‐tolerated with nonlinear pharmacokinetics. It shows dose‐proportional increase in plasma exposure above 100 mg, and has no marked changes in exposure when co‐administered with sitagliptin. SB756050 has highly variable pharmacodynamic effects both within between doses and dose groups, with increases in glucose seen at the two lowest doses and no reduction in glucose seen at the two highest doses. The glucose effects of SB756050 t sitagliptin are comparable to those of sitagliptin alone, even though gut hormone plasma profiles are different. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/mL (109.87 mM)
|
| Keywords | G protein-coupled Bile Acid Receptor 1 | inhibit | TGR5 | Inhibitor | GPBAR1 | G-protein coupled receptor 19 | SB756050 | GPCR19 |
| Inhibitors Related | Ursodeoxycholic acid sodium | SBI-115 | BAR502 | TC-G 1005 | Deoxycholic acid | Triamterene | L-692429 | BAR 501 impurity | Deoxycholic acid sodium salt | BAR501 | Hyodeoxycholic acid | PEN (human) aceate |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Metabolism Disease Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States