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Postion:Product Catalog >SB756050
SB756050
  • SB756050

SB756050 NEW

Price $35 $56 $98
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-17

Product Details

Product Name: SB756050 CAS No.: 447410-57-3
Purity: 98.78% Supply Ability: 10g
Release date: 2024/11/17

Product Introduction

Bioactivity

名稱SB756050
描述SB756050 is a specific TGR5 agonist.
體外活性TGR5 is a potential target for the therapy of type 2 diabetes (T2D). Thus, SB756050 is used in phase 1clinical trials for the treatment of type 2 diabetes.
體內活性SB756050 is well‐tolerated with nonlinear pharmacokinetics. It shows dose‐proportional increase in plasma exposure above 100 mg, and has no marked changes in exposure when co‐administered with sitagliptin. SB756050 has highly variable pharmacodynamic effects both within between doses and dose groups, with increases in glucose seen at the two lowest doses and no reduction in glucose seen at the two highest doses. The glucose effects of SB756050 t sitagliptin are comparable to those of sitagliptin alone, even though gut hormone plasma profiles are different.
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 55 mg/mL (109.87 mM)
關鍵字G protein-coupled Bile Acid Receptor 1 | inhibit | TGR5 | Inhibitor | GPBAR1 | G-protein coupled receptor 19 | SB756050 | GPCR19
相關產品Ursodeoxycholic acid sodium | SBI-115 | BAR502 | TC-G 1005 | Deoxycholic acid | Triamterene | L-692429 | BAR 501 impurity | Deoxycholic acid sodium salt | BAR501 | Hyodeoxycholic acid | PEN (human) aceate
相關庫經典已知活性庫 | 膜蛋白靶向化合物庫 | ReFRAME 相關化合物庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 臨床期小分子藥物庫 | 已知活性化合物庫 | GPCR靶點分子庫 | 抗代謝疾病化合物庫 | 抗癌藥物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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