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Postion:Product Catalog >SB 258719
SB 258719
  • SB 258719

SB 258719 NEW

Price $50 $82 $166
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-15

Product Details

Product Name: SB 258719 CAS No.: 195199-95-2
Purity: 98.59% Supply Ability: 10g
Release date: 2024/11/15

Product Introduction

Bioactivity

名稱SB 258719
描述SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.
體外活性SB 258719 antagonised surmountably 5-CT-stimulated adenylyl cyclase activity. Schild analysis of the antagonism by SB 258719 gave a pA2 of 7.2±0.2 and slope not significantly different from 1, consistent with competitive antagonism[3].
體內(nèi)活性SB 258719 (5-20 mg/kg, i.p.) reversed the hypothermic effect of 5-CT in mice[1], attenuated increased Wnt/β-catenin activity in HCC cell lines and patient-derived primary tumor tissues in the presence of 5-HT, and reduced tumor growth in vivo[2].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 250 mg/mL (738.53 mM)
關(guān)鍵字5-HT Receptor | 5-hydroxytryptamine Receptor | agonism | Inhibitor | inverse | SB258719 | hydrochloride | partial | apparent | selective | inhibit | SB-258719 | SB 258719 | Serotonin Receptor | affinity
相關(guān)產(chǎn)品Serotonin hydrochloride | Alverine citrate | Olanzapine | Dapoxetine hydrochloride | CLOZAPINE N-OXIDE | Mirtazapine | Amitriptyline hydrochloride | Cloperastine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Fluoxetine hydrochloride | Cinchonidine
相關(guān)庫疼痛相關(guān)化合物庫 | 經(jīng)典已知活性庫 | 神經(jīng)信號分子庫 | 膜蛋白靶向化合物庫 | 抑制劑庫 | 已知活性化合物庫 | GPCR靶點分子庫 | 抗癌化合物庫 | 5-羥色胺分子庫 | 抗癌活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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