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Postion:Product Catalog >SB 204990
SB 204990
  • SB 204990

SB 204990 NEW

Price $39 $93 $163
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-08

Product Details

Product Name: SB 204990 CAS No.: 154566-12-8
Purity: 99.6% Supply Ability: 10g
Release date: 2024/11/08

Product Introduction

Bioactivity

名稱SB 204990
描述SB 204990 is a lactone prodrug of SB-201076, a potent and specific ATP citrate lyase inhibitor.
體外活性METHODS: Primary hepatocytes were treated with SB-204990 (10 μM, 16 hours) under different experimental conditions to determine the effects occurring early after exposure to the Acly inhibitor SB-204990. RESULTS Phosphorylation of pThr 172 Ampk and pSer 79 Acc was reduced in primary hepatocytes treated with SB-204990 for 16 hours, while markers of Sirt1 or mTOR activity were absent. [1]
體內(nèi)活性METHODS: Mice were treated with SB-204990 (30 mg/kg body weight; oral gavage; treatment for 3 hours) to determine whether SB-204990 could induce effects in mitochondria in vivo. RESULTS Freshly isolated liver mitochondria from mice showed blocking and limiting effects on ADP-induced and FCCP-induced increases in OCR, respectively. [1]
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 100 mg/mL (256.89 mM)
H2O : 10 mg/mL (25.69 mM), Sonication is recommended.
關(guān)鍵字SB 204990 | Inhibitor | inhibit | ACLY | SB204990 | SB-204990 | ATP Citrate Lyase
相關(guān)產(chǎn)品Forrestiacids J | Forrestiacids K | BMS-303141 | Hydroxycitric acid tripotassium hydrate | (-)-Hydroxycitric acid lactone | MEDICA16 | 2-Furoic acid | NDI-091143 | Bempedoic acid | (-)-Hydroxycitric acid
相關(guān)庫經(jīng)典已知活性庫 | 抑制劑庫 | NO PAINS 化合物庫 | 代謝化合物庫 | 脂代謝化合物庫 | 已知活性化合物庫 | 共價抑制劑庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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