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Postion:Product Catalog >SAR407899
SAR407899
  • SAR407899

SAR407899 NEW

Price $33 $52 $85
Package 2mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-15

Product Details

Product Name: SAR407899 CAS No.: 923359-38-0
Purity: 99.42% Supply Ability: 10g
Release date: 2024/11/15

Product Introduction

Bioactivity

名稱SAR407899
描述SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
動物實驗Compared the effects of SAR407899, the Rho-kinase inhibitor Y-27632 and the PDE5 inhibitor sildenafil for their ability to relax corpus cavernosum strips contracted with phenylephrine in healthy and diabetic animals. Strips were obtained from WKY, spontaneous hypertensive (SHR), control CD, and diabetic CD rats, humans, control and diabetic rabbits. Diabetes was induced by streptozotocin or alloxan injection. In vivo penile erection (length) induced by drugs was measured in conscious rabbits[1].
體內(nèi)活性In vivo, SAR407899 dose-dependently induced rabbit penile erection, with greater potency and longer duration of action than sildenafil[1].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 6 mg/mL (24.56 mM)
關(guān)鍵字Rho-associated kinase | ROK | SAR-407899 | Rho-kinase | ROCK | Rho-associated protein kinase | SAR 407899 | inhibit | SAR407899 | Inhibitor
相關(guān)產(chǎn)品GSK180736A | CCG-257081 | SKLB-163 | SAR407899 hydrochloride | RKI-1447 | Belumosudil | Fasudil hydrochloride | Y-27632 dihydrochloride | Tofacitinib | Y-27632 | ROCK-IN-5 | Thiazovivin
相關(guān)庫經(jīng)典已知活性庫 | ReFRAME 相關(guān)化合物庫 | 激酶抑制劑庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 已知活性化合物庫 | 抗癌藥物庫 | TGF-β/Smad靶點化合物庫 | 抗高血壓化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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