Salvianolic acid B NEW
| Price | $60 | $210 |
| Package | 5mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: Salvianolic acid B | CAS No.: 115939-25-8 |
| Purity: 99.84% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | Salvianolic acid B |
| 描述 | Salvianolic acid B (Dan Shen Suan B), a natural product from Salvia miltiorrhiza, is a water-soluble antioxidant. Salvianolic acid B has antiplatelet aggregation, anticoagulant, and antithrombotic effects, and is commonly used in the study of microcirculatory disorders. |
| 體外活性 | METHODS: Human lung cancer cell lines NCI-H2030 and NCI-H1650 were treated with Salvianolic acid B (100-600 μM) for 24-48 h. Cell viability was measured by CCK-8 assay. RESULTS: At 24 h of exposure, the cell viability of NCI-H2030 and NCI-H1650 cells was significantly reduced when the concentration of Salvianolic acid B reached 400 μM. At 48 h exposure, the cell viability was significantly reduced until the concentration reached 300 μM, which was significantly higher than that of the control group. [1] METHODS: Human renal proximal tubule cells HK-2 were treated with TGF-β1 (2.5 ng/mL) and Salvianolic acid B (1-10 μM) for 24 h. Gene expression levels were measured by RT-PCR. RESULTS: TGF-β1 significantly inhibited the expression of E-cadherin mRNA in HK-2 cells, while 1-10 μM Salvianolic acid B prevented the loss of its expression. [2] |
| 體內(nèi)活性 | METHODS: To investigate the effects of peripheral arterial disease (PAD), Salvianolic acid B (15 mg/kg) was intraperitoneally injected once daily for 12 days into a hindlimb ischemia mouse model. RESULTS: The Salvianolic acid B group showed significant improvement in blood perfusion, capillary density, muscle edema and M2 marker gene expression. Salvianolic acid B had a protective effect in PAD and enhanced macrophage polarization through the SIRT1/PI3K/AKT pathway. [3] |
| 存儲條件 | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 25 mg/mL (34.79 mM) |
| 關(guān)鍵字 | 121521-90-2 | T2727 | Salvianolic acid B |
| 相關(guān)庫 | 天然多酚類化合物庫 | 中藥單體化合物庫 | 植物來源化合物庫 | 毒性化合物庫 | 藥物功能重定位化合物庫 | 天然產(chǎn)物庫 | 神經(jīng)保護(hù)化合物庫 | 高通量篩選天然產(chǎn)物庫 | 抗COVID-19化合物庫 | 古代經(jīng)典名方目錄分子庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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