Product Details
| Product Name:
Rostafuroxin |
CAS No.:
156722-18-8 |
| Purity:
99.08% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Rostafuroxin |
| Description | Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension. |
| Kinase Assay | Kinase assay: Activity assays are conducted using Lance Ultra time-resolved fluorescence resonance energy transfer (TR-FRET) technology from Perkin-Elmer. Briefly, 10 ng/mL FLT3 enzyme, a serial diluted G-749, 80 nM substrate of ULight-poly-GT peptide and variable amounts of ATP (8.5 μM to 1088 μM) are mixed in kinase assay buffer (50 mM HEPES pH 7.5, 10 mM MgCl2, 1 mM EGTA, 2 mM DTT and 0.01% Tween-20) and are added to a 384-well OptiPlate-384 in a volume of 10 μL. Kinase reactions are incubated at room temperature for up to 1 h and then stopped by the addition of 5 μL of 10 mM EDTA. A volume of 5 μL of the specific Eu-labeled-anti-phosphopeptide antibody diluted in LANCE Detection Buffer is then added to a final concentration of 2 nM. After 30-minute incubation, assay plates are incubated at 23°C and the LANCE signal is measured on an EnVision Multilabel Reader. Excitation wavelength is set at 320 nm and emission monitored at 615 nm (donor) and 665 nm (acceptor). The IC50 is calculated using nonlinear regression analysis analysis by GradPad Prism 5. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (133.5 mM)
|
| Keywords | ATP1A1 | RSV | Respiratory syncytial virus | Na+/K+ ATPase | phosphorylation | inhibit | PST-2238 | Tyr845 | Sodium potassium pump | EGFR | PST2238 | Rostafuroxin | antihypertensive | RSV-GFP | Inhibitor | digitoxigenin | Ouabain |
| Inhibitors Related | Tirofiban hydrochloride monohydrate | Sodium oleate | Ribavirin | Roflumilast | trans-Aconitic acid | Phlorizin | Chlorpropamide | Revaprazan hydrochloride | Oleic acid | Esomeprazole Sodium | Trichlormethiazide | Amentoflavone |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | Orally Active Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
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Suppliers |
Update time |
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$15.00/1KG |
|
Zhuozhou Wenxi import and Export Co., Ltd
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2021-07-10 |
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$15.00/1KG |
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Zhuozhou Wenxi import and Export Co., Ltd
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2021-07-09 |
United States