RORγt inverse agonist 13 NEW
| Price | $48 | $118 | $188 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: RORγt inverse agonist 13 | CAS No.: 2170477-75-3 |
| Purity: 99% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | RORγt inverse agonist 13 |
| Description | RORγt inverse agonist 13 (Compound 3i) is a potent, orally active, and selective inverse agonist for RORγt with an IC50 of 63.8 nM, exhibiting improved drug-like properties[1]. |
| In vitro | RORγt inverse agonist 13 (Compound 3i) demonstrates 76% inhibition at 0.3 μM in the Th17 cell differentiation assay[1]. |
| In vivo | RORγt inverse agonist 13 (Compound 3i, 25 mg/kg, orally, twice daily) demonstrates an excellent in vivo PK profile and good efficacy in an IMQ-induced psoriasis mouse model[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 10 mg/mL (19.48 mM), Sonication is recommended. |
| Keywords | ROR | RORγt inverse agonist-13 | RAR-related orphan receptor | inhibit | RORγt inverse agonist13 | RORrt inverse agonist 13 | Inhibitor | RORγt inverse agonist 13 | RORgammat inverse agonist 13 |
| Inhibitors Related | S18-000003 | T0901317 | GSK2981278 | Nobiletin | XY101 | Cholesterol | AZD-0284 | Melatonin | SR2211 | Cabozantinib hydrochloride | RORγt Inverse agonist 6 | ML 209 |
| Related Compound Libraries | Nuclear Receptor Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Orally Active Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Transcription Factor-Targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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