Ronacaleret HCl NEW
| Price | $290 | $713 | $987 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: Ronacaleret HCl | CAS No.: 702686-96-2 |
| Purity: 99.58% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | Ronacaleret HCl |
| 描述 | Ronacaleret HCl (SB-751689) is a small molecule CaSR antagonist for the treatment of endocrine and metabolic diseases, skin and musculoskeletal disorders. |
| 體內(nèi)活性 | For 569 postmenopausal women with low BMD offered open-label 20 μg teriparatide sc once daily or were randomized to 100, 200, 300, or 400 mg oral Ronacaleret HCl once daily, 70 mg alendronate once weekly, or placebo and were followed for up to 12 months.Results: With Ronacaleret HCl, the increases in lumbar spine BMD at 12 months (0.3-1.6%) were significantly lower than those attained with teriparatide (9.1%) or alendronate (4.5%). There were small decreases in total hip, femoral neck, and trochanter BMD at month 12 with Ronacaleret HCl compared with increases in the teriparatide and alendronate arms. Bone turnover markers increased in the Ronacaleret HCland teriparatide arms and decreased in the alendronate arm. PTH elevations with Ronacaleret HCl were prolonged relative to those previously reported with teriparatide. Conclusion: The densitometric findings in the context of prolonged PTH elevation and increased bone turnover suggest Ronacaleret HClinduces mild hyperparathyroidism. Ronacaleret HCl only modestly increased lumbar spine BMD and decreased BMD at hip sites.[1] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 1 mg/mL, Sonication is recommended. |
| 關(guān)鍵字 | Ronacaleret HCl |
| 相關(guān)產(chǎn)品 | SB-423562 | Strontium ranelate | Cinacalcet | Tecalcet Hydrochloride | NPS-2143 | Strontium chloride | Calindol hydrochloride | Poly-D-lysine hydrobromide (MW 30000-70000) | Cinacalcet hydrochloride | AC265347 | Evocalcet | Gadolinium chloride |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 膜蛋白靶向化合物庫(kù) | 已知活性化合物庫(kù) | GPCR靶點(diǎn)分子庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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