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Postion:Product Catalog >RJW100
RJW100
  • RJW100

RJW100 NEW

Price $397 $834 $1130
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-12

Product Details

Product Name: RJW100 CAS No.: 1276664-20-0
Purity: 99.15% Supply Ability: 10g
Release date: 2024/11/12

Product Introduction

Bioactivity

名稱RJW100
描述RJW100 is a compound that acts as a potent agonist of liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1), exhibiting pEC50 values of 6.6 and 7.5, respectively. Additionally, RJW100 induces robust activation of the miR-200c (miRNA-200c, microRNA-200c) promoter.
體外活性RJW100 (compound 24-exo) treatment significantly increases small/short heterodimer partner (SHP) transcripts in a dose-dependent manner starting at 5 μM. It almost completely displaces bound PIP2 phospholipid from SF-1 at 1 μM. Using hLRH-1 LBD alone without any phospholipids, a clear dose-dependent shift in hLRH-1 LBD native PAGE migration is observed with RJW100 (compound 24-exo; 0-100 μM) binding[1]. RJW100 strongly activates the miR-200c promoter and effectively downregulates ZEB1 and ZEB2 proteins[2].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 55 mg/mL (142.27 mM)
關(guān)鍵字RJW 100 | RJW100 | RJW-100
相關(guān)庫經(jīng)典已知活性庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.
2024-10-28
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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