Product Details
| Product Name:
Risarestat |
CAS No.:
79714-31-1 |
| Purity:
98.39% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Risarestat |
| Description | Risarestat (CT-112) is a potent aldose reductase inhibitor and thyroid hormone receptor (TR) antagonist for the treatment of hypoglycemia. |
| In vivo | In a dose-dependent manner, Risarestat inhibits the accumulation of dulcitol, with the exception of the 1.0% solution, which exhibits activity comparable to the 0.25% solution[1]. Following instillation, Risarestat peaks in the corneal epithelium, stroma, endothelium, and aqueous humor within 30 minutes, gradually diminishing time-dependently over 24 hours. Risarestat remains detectable in the lens for up to 24 hours, with a peak concentration observed at 2 hours after instillation[2]. In the group treated with Risarestat, the anterior surface area of superficial cells significantly decreases from a mean value of 881 to 728 microns^2. Corneal sensitivity significantly improves from 5.36 to 1.37 g/mm^2[3]. Animals treated with Risarestat show a significant increase in the mean blink response compared to untreated galactose-fed rats, and the response does not differ significantly from controls toward the completion of the 7-month study. However, animals treated topically with Risarestat and untreated galactose-fed rats develop bilateral nuclear cataracts within 3 weeks[3]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (154.60 mM), Sonication is recommended.
|
| Keywords | CT-112 | CT112 | Risarestat |
| Inhibitors Related | MK 0434 | Alconil | Epalrestat | 2-Chloro-1-(4-fluorobenzyl)benzimidazole | Lidorestat | Alpha-Estradiol | Isoliquiritigenin | Finasteride | Epristeride | Dutasteride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States