Product Details
| Product Name:
RIG012 |
CAS No.:
2642218-43-5 |
| Purity:
99.53% |
Supply Ability:
10g |
| Release date:
2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | RIG012 |
| 描述 | RIG012 is a potent RIG-I inhibitor with an IC50 of 0.71 μM (measured by NADH-coupled ATPase), and it inhibits the expression of IFN-β and ISG hRsad2. |
| 體外活性 | RIG012 (1, 1.25, 1.5, 2, 2.5, 3, 4 μM) has potent dose-dependent inhibition of RIG-I signaling in HEK293T cells co-transfected with expression plasmids and reporter plasmids.[1]
RIG012 (1.25, 2.25, 4.5, 9, 18 μM) has potent dose-dependent inhibition of IFN-β and ISG hRsad2 expression in A549 cells.[1]
RIG012 contains a strong chromophore that absorbs in the visible range (λmax of 470 nm). Upon binding to RIG-I, the 470 nm absorption band of RIG012 undergoes a significant hyperchromic shift toward higher intensity values.[1] |
| 存儲(chǔ)條件 | Shipping with blue ice. |
| 溶解度 | DMSO : 7 mg/mL (19.48 mM), Sonication is recommended.
|
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 抑制劑庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States