Rifabutin NEW
| Price | $42 | $55 | $79 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-04 |
Product Details
| Product Name: Rifabutin | CAS No.: 72559-06-9 |
| Purity: 99.8% | Supply Ability: 10g |
| Release date: 2024/11/04 |
Product Introduction
Bioactivity
| 名稱 | Rifabutin |
| 描述 | Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. |
| 體外活性 | In chimeric mice, the combined use of Rifabutin (100 mg/kg) and emtricitabine (10 mg/kg) resulted in a 75% survival rate among mice infected with either Toxoplasma or Plasmodium. Additionally, in these mice, Rifabutin significantly increased human CYP3A4 mRNA expression (by 7.4-fold), CYP3A4 protein levels (by 3.0-fold), testosterone 6β-hydroxylase activity (by 2.4-fold), and dexamethasone 6-hydroxylase activity (by 1.9-fold). |
| 體內(nèi)活性 | Rifabutin exhibits broad-spectrum antimicrobial activity and, compared to rifampicin, demonstrates higher potency in vitro against the Mycobacterium avium complex (MAC), Mycobacterium tuberculosis, and Mycobacterium leprae. It is also effective against Group A Streptococcus, Campylobacter jejuni, Neisseria gonorrhoeae, Haemophilus influenzae, Staphylococcus species, Haemophilus ducreyi, Helicobacter pylori, Neisseria meningitidis, Chlamydia trachomatis, and Toxoplasma gondii. While rifabutin is active against most atypical mycobacteria, including Mycobacterium kansasii, it is less effective against Mycobacterium chelonae. Its isoenzyme selectivity closely resembles that of rifampicin, although rifampin induces to a greater extent, by 2-4 times. Furthermore, rifabutin enhances the glucuronidation of β-estradiol, 4-hydroxytamoxifen, and 1-naphthol by 2-3 times. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 38 mg/mL (44.9 mM) DMSO : 18.33 mg/mL (21.65 mM) |
| 關(guān)鍵字 | inhibit | Antibiotic | Inhibitor | Bacterial | LM427 | LM 427 | Rifabutin |
| 相關(guān)產(chǎn)品 | Neomycin sulfate | Kanamycin sulfate | Sulfamethoxazole sodium | Guanidine hydrochloride | Doxycycline | Thymidine | Dimethyl sulfoxide |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 抗癌臨床化合物庫(kù) | 藥物功能重定位化合物庫(kù) | 抗病毒庫(kù) | 抑制劑庫(kù) | 抗癌上市藥物庫(kù) | FDA 上市藥物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 抗癌藥物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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