Ribostamycin sulfate NEW
| Price | $31 | $48 | $65 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-06 |
Product Details
| Product Name: Ribostamycin sulfate | CAS No.: 53797-35-6 |
| Purity: 99.57% | Supply Ability: 10g |
| Release date: 2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | Ribostamycin sulfate |
| 描述 | Ribostamycin sulfate (Vistamycin sulfate) , an aminoglycoside antibiotic, contains a neutral sugar moiety and is produced by Streptomyces ribosome. |
| 體外活性 | Compared to other antibiotics, Ribostamycin (400 mg/kg/day) exhibits the lowest ototoxicity and maintains lower drug concentrations in the inner ear fluid of guinea pigs. Ribostamycin demonstrates minimal ototoxicity to both the cochlea and vestibular apparatus in guinea pigs. |
| 體內(nèi)活性 | Ribostamycin effectively inhibits aminoglycoside-modifying enzymes in gentamicin-resistant Pseudomonas aeruginosa without suppressing protein disulfide isomerase (PDI) activity, although it does inhibit its chaperone activity. At a 100:1 molar ratio with PDI, Ribostamycin nearly completely inhibits chaperone activity. The dissociation constant (KD) for Ribostamycin binding to immunogenic PDI is 0.319 mM. Additionally, Ribostamycin exhibits antibacterial activity against Borrelia burgdorferi with a minimum inhibitory concentration (MIC) of 18.7 mg/L. At a concentration of 16 mcg/mL, Ribostamycin inhibits P. stagnora, P. zopfii, and P. wickerhamii strains by 100%, 100%, and 95%, respectively. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : Insoluble H2O : 10 mM |
| 關(guān)鍵字 | Inhibitor | Vistamycin | inhibit | Ribostamycin sulfate | Antibiotic | Vistamycin Sulfate | Bacterial | Ribostamycin | Ribostamycin Sulfate |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 天然產(chǎn)物庫 | 藥物功能重定位化合物庫 | 糖類及苷類化合物庫 | 微生物天然產(chǎn)物庫 | 高通量篩選天然產(chǎn)物庫 | 抗感染天然產(chǎn)物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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