(R)-Lisofylline NEW
| Price | $227 | Get Latest Price | Get Latest Price |
| Package | 1mg | 10mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: (R)-Lisofylline | CAS No.: 100324-81-0 |
| Purity: 99.50% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | (R)-Lisofylline |
| 描述 | (R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 μM) that interrupts IL-12 signaling-mediated STAT4 activation, making it useful for studies on the treatment of type 1 diabetes and autoimmune disorders. |
| 體外活性 | (R)-Lisofylline inhibits IL-12-induced T cell proliferation and Th1 differentiation without affecting IL-12 secretion[1]. |
| 體內(nèi)活性 | In NOD mice, (R)-Lisofylline prevents β cell dysfunction by inhibition of STAT4 phosphorylation and ameliorates experimental allergic encephalomyelitis. (R)-Lisofylline reduces the impairment of insulin secretion induced by IL-1β in cultured rat islet cells, suppresses IFN-γ production, the onset of diabetes, and macrophage infiltration into islets. (R)-Lisofylline improves insulin response and lowers glucose levels in Streptozotocin-treated rats after the oral glucose tolerance test. In rats given IL-1 intratracheally (R)-Lisofylline pretreatment reduces lung leak but does not decrease neutrophil accumulation in lungs. (R)-Lisofylline improves survival in mice injected with a lethal dose of LPS and ameliorates sepsis-induced lung injury in minipigs[2]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 45 mg/mL (160.53 mM) |
| 關(guān)鍵字 | Pentoxifylline | Inhibitor | STAT | anti-inflammatory | inhibit | STAT4 | lysophosphatidic | (R)Lisofylline | acid | IL-12 | IFN-γ | diabetes | immunomodulator | Lisofylline | (R) Lisofylline | (R)-Lisofylline | acyltransferase | LPS | metabolite | Lisophylline |
| 相關(guān)產(chǎn)品 | Nifuroxazide | Balsalazide sodium hydrate | Fludarabine | Scutellarin | Niclosamide | 2-(1,8-naphthyridin-2-yl)phenol | CASIN | Diosgenin | Niclosamide olamine | Artesunate | Alantolactone | Stattic |
| 相關(guān)庫 | 抗肺癌化合物庫 | 抗胰腺癌化合物庫 | 抗癌細胞代謝庫 | 抗癌臨床化合物庫 | 抗前列腺癌化合物庫 | 臨床期小分子藥物庫 | 抗癌化合物庫 | 抗肝癌化合物庫 | 抗癌藥物庫 | 轉(zhuǎn)錄因子庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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