Product Details
| Product Name:
(R)-Equol |
CAS No.:
221054-79-1 |
| Purity:
99.04% |
Supply Ability:
10g |
| Release date:
2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | (R)-Equol |
| 描述 | (R)-Equol ((+)-Equol) is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively. |
| 體外活性 | (R)-Equol produced a dose-dependent inhibitory effect on the invasive ability of MDA-MB-231 cells, and this inhibitory effect was obvious at the highest test concentration (50 μM).Following 48-h exposure to (R)-Equol, invasion is reduced by 62% (p=0.009, versus untreated cells) with 50 μM (R)-Equol. Matrix metalloproteinase-2 (MMP-2) expression is significantly down-regulated following treatment with 50 μM (R)-Equol (p=0.035) [2]. |
| 體內(nèi)活性 | In animals, (R)-Equol significantly reduces the number of palpable tumors over time compared to controls (P=0.002). The number of palpable tumors per rat in the (R)-Equol-fed group is significantly lower than in rats treated with S-(-)equol (P=0.008). (R)-Equol-fed animals exhibit 43% fewer tumors than the control group, with this difference being highly statistically significant (P=0.004). The number of tumors per tumor-bearing animal is significantly lower in (R)-Equol-fed animals compared to controls (3.3±0.4 versus 5.5±0.5, P=0.004). At necropsy, the mean (±SEM) tumor weight per animal for (R)-Equol-fed rats (5.3±1.1 mg) is significantly reduced (P=0.04) compared to controls (9.9±1.4 mg). Feeding the (R)-Equol diet also results in significantly increased tumor latency (P=0.003) [3]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 100 mg/mL (412.76 mM), Sonication and heating are recommended.
|
| 關(guān)鍵字 | (R)-Equol | (R) Equol | Equol | (R)Equol | Inhibitor | Estrogen Receptor/ERR | inhibit |
| 相關(guān)產(chǎn)品 | Kaempferol | Tamoxifen | Mifepristone | Estradiol | Astragaloside IV | Estradiol benzoate | Melatonin | Allura Red AC | Natamycin | Ethisterone |
| 相關(guān)庫 | 核受體化合物庫 | 經(jīng)典已知活性庫 | 內(nèi)分泌激素分子庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | 人代謝物化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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