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Postion:Product Catalog >API>Nervous system drugs>Antipsychotics>Quetiapine hemifumarate
Quetiapine hemifumarate
  • Quetiapine hemifumarate

Quetiapine hemifumarate NEW

Price $46
Package 500mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Quetiapine hemifumarate CAS No.: 111974-72-2
Purity: 97.63% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameQuetiapine hemifumarate
DescriptionQuetiapine hemifumarate (ICI-204636), an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression.
Kinase AssayCDK activity assays: CDK assays for IC50 determinations and kinetic evaluation are performed in 96-well filter plates. All CDK-cyclin kinase complexes are expressed in insect cells through baculovirus infection and purified. The substrate for the assays is a fragment (amino acids 792–928) of pRb fused to GST (GST?RB-Cterm). The total reaction volume is 0.1 mL containing a final concentration of 20 mM Tris-HCl, pH 7.4, 50 mM NaCl, 1 mM dithiothreitol, 10 mM MgCl2 25 μM ATP (for CDK4-cyclin D1, CDK6-cyclin D2, and CDK6-cyclin D3) containing 0.25 μCi of [γ-32P]ATP, 20 ng of enzyme, 1 μg of GST?RB-Cterm, and appropriate dilutions of inhibitor. All components except the [γ-32P]ATP are added to the wells, and placed on a plate mixer for 2 min. The reaction is started by adding the [γ-32P]ATP, and incubated at 25℃ for 15 min. The reaction is terminated by addition of 0.1 mL of 20% trichloroacetic acid, and the plate is kept at 4?℃ for at least 1 hr to allow the substrate to precipitate. The wells are then washed five times with 0.2 mL of 10% trichloroacetic acid, and radioactive incorporation is determined with a β plate counter.
In vitroQuetiapine alters the neurotransmitter norepinephrine in the brain's limbic system and the expression of c-fos. It also exhibits antipsychotic activity, diminishing the tendency to induce extrapyramidal symptoms and persistently increase prolactin levels. Its effectiveness in behavioral and biochemical assays mirrors that of clozapine, suggesting it may possess neuroprotective properties.
In vivoQuetiapine has an affinity for dopamine-2 receptors similar to that of clozapine, and it exhibits comparable affinity for various neurotransmitter receptors, including serotonin, histamine, dopamine, and adrenergic receptors.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 25 mg/mL (28.31 mM), Sonication is recommended.
KeywordsQuetiapine Hemifumarate | Quetiapine hemifumarate | 5-hydroxytryptamine Receptor | Inhibitor | Quetiapine | anxiolytic | 5-HT Receptor | inhibit | Antidepressant | 5-HT2A | 5-HT1A | Serotonin Receptor | 5-HT2C | ICI204636 | Dopamine Receptor | ICI 204636
Inhibitors RelatedAlverine citrate | Dapoxetine hydrochloride | Octopamine hydrochloride
Related Compound LibrariesBioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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