Punicalin NEW
| Price | $43 | $122 | $198 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: Punicalin | CAS No.: 65995-64-4 |
| Purity: 99.95% | Supply Ability: 10g |
| Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | Punicalin |
| 描述 | Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner, with an IC50 of 0.11 microg/ml (0.14 microM). |
| 動物實驗 | Edema in the left hind paw of rats was induced by injecting 0.05 ml of 1% (w/v) carrageenan into the limb.?Animals were divided into six groups with eight animals in each group.?The drug test groups were treated with 5 or 10 mg/kg body weight of each component 1 hr before carrageenan injection.?The animals in the control group received saline.?Another group of rats was administered 5 mg/kg indomethacin as a standard anti-inflammatory drug. |
| 體外活性 | The edema after carrageenan injection is believed to be biphasic in nature.?The initial phase, beginning 1 hr after carrageenan administration, is due to the release of histamine and serotonin.?The second phase occurs 2 to 5 hr after carrageenan administration.??is induced by the release of bradykinin, protease, prostaglandin and lysosome ?.?It has been reported that the second phase of edema is sensitive to most clinically effective anti-inflammatory agents, such as indomethacin.?However, that treatment with punicalagin and punicalin is effective against both phases of inflammation induced by carrageenan. |
| 體內(nèi)活性 | Punicalagin and punicalin were the active components of T. catappa L., a hepatoprotective crude drug used in Southern Asia, and both found to exhibit great antioxidant activity and hepatoprotective effect on CC14- or acetaminophen-induced liver damages. Even if they had great antioxidant effects in smaller concentration in vitro, treatment with larger doses of punicalagin and punicalin yield liver cell damage in rats.?In studying their anti-inflammatory effects, similar results were also observed. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 25 mg/mL (31.95 mM) |
| 關鍵字 | hepatitis | inhibit | Punicalin | virus | Hepatitis B virus | Inhibitor | Tannin | HBV | anti-inflammatory |
| 相關產(chǎn)品 | Stavudine | 5-Fluorouracil | Emtricitabine | Kaempferol | Dolutegravir intermediate-1 | Dextran sulfate sodium salt (MW 4500-5500) | Lamivudine | Cetylpyridinium Chloride | Chloroquine phosphate | Valproic Acid | Decanedioic acid | Tenofovir |
| 相關庫 | 抗癌天然產(chǎn)物庫 | 經(jīng)典已知活性庫 | 植物來源化合物庫 | 天然產(chǎn)物庫 | 抑制劑庫 | 高通量篩選天然產(chǎn)物庫 | 抗感染天然產(chǎn)物庫 | 抗衰老化合物庫 | 抗病毒中藥單體化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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