Prucalopride has a highly selective and specific 5-HT4 receptor activation, can stimulate the intestinal peristaltic reflex in rats, guinea pigs and humans, enhance colonic contraction, and accelerate gastric emptying. In healthy volunteers, Pru can shorten the passage time of the upper gastrointestinal tract and colon. In patients with constipation, Pru can increase the frequency of defecation and reduce the hardness of stool. Pru is mainly used for the treatment of various constipation, sluggish and weak gastrointestinal peristalsis and false intestinal obstruction after surgery. Pru is more effective and more selective than Cisapride and is 500 times more selective than Cisapride.

Indication

Pucaprid has a highly selective and specific 5-HT4 receptor activation, can stimulate the intestinal peristaltic reflex in rats, guinea pigs and humans, enhance colonic contraction, and accelerate gastric emptying. In healthy volunteers, Pru can shorten the passage time of the upper gastrointestinal tract and colon. In patients with constipation, Pru can increase the frequency of defecation and reduce the hardness of stool. Pru is mainly used for the treatment of various constipation, sluggish and weak gastrointestinal peristalsis and false intestinal obstruction after surgery. Pru is more effective and more selective than Cisapride and is 500 times more selective than Cisapride.