Pranlukast NEW
| Price | $50 | $72 | $90 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-05 |
Product Details
| Product Name: Pranlukast | CAS No.: 103177-37-3 |
| Purity: 99.85% | Supply Ability: 10g |
| Release date: 2024/11/05 |
Product Introduction
Bioactivity
| 名稱 | Pranlukast |
| 描述 | Pranlukast (ONO-1078) is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens. |
| 體外活性 | Pranlukast significantly reduces the volume of injury in the cortical and hippocampal CA1 regions of the ischemic hemisphere in mice and increases neuronal density. Additionally, Pranlukast markedly thins the scar wall in the ischemic hemisphere of mice. |
| 體內(nèi)活性 | In sensitized guinea pig tracheas, 5 mM of either Pranlukast or Zafirlukast significantly inhibited ovalbumin-induced secretion by 70% and 65%, respectively. These compounds also markedly inhibited 35SO4 release triggered by 10 mM LTD4 in a concentration-dependent manner, with Pranlukast showing a peak inhibition of 83% and Zafirlukast 78% at 10 mM, having IC50 values of 0.3 mM and 0.6 mM, respectively. Pranlukast suppressed the activation of NF-κB in 1.3% DMSO-differentiated U-937 and Jurkat cells, with inhibition rates of 40% and 30%; it also demonstrated a dose-dependent inhibition of NF-κB activation in combination with MK-571. Pranlukast and MK-571 diminished LPS-induced IL-6 production in PBMCs by approximately 65% and 15%. Additionally, Pranlukast inhibited the activation of NF-κB induced by phorbol 12-myristate 13-acetate and significantly reduced LPS-induced MUC2 mRNA expression in NCI-H292 cells, as determined by reverse transcription-polymerase chain reaction. Pranlukast also suppressed the expression of the MUC2 gene in LPS-stimulated HM3-MUC2 cells. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 45 mg/mL (93.46 mM) |
| 關(guān)鍵字 | Inhibitor | inhibit | Leukotriene Receptor | ONO 1078 | ONO1078 | Pranlukast |
| 相關(guān)產(chǎn)品 | Acetylcysteine | Diethylmaleate | Glucosamine | Lidocaine hydrochloride | L-Arginine | Apremilast | Indole-3-carbinol | Diallyl disulfide |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 抗癌上市藥物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | GPCR靶點(diǎn)分子庫 | 人代謝物化合物庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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