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Postion:Product Catalog >PMX 205 acetate(514814-49-4 free base)
PMX 205 acetate(514814-49-4 free base)
  • PMX 205 acetate(514814-49-4 free base)

PMX 205 acetate(514814-49-4 free base) NEW

Price $113 $296 $389
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: PMX 205 acetate(514814-49-4 free base) Purity: 99.4%
Supply Ability: 10g Release date: 2024/11/19

Product Introduction

Bioactivity

NamePMX 205 acetate(514814-49-4 free base)
DescriptionPMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).
In vitroPMX 205 (PMX205) group is in between 0.09893 to 0.2465, EP54 group, 0.02724 to 0.1748 and Tamoxifen group, the value recorded in between 0.09880 to 0.2464. For the 48 h plate of incubation time, only two groups of PMX 205 and Tamoxifen show a significant result. The values recorded are in between 0.04987 to 0.3273 and 0.5777 to 0.8551 respectively. For the 72 h plate, only one group shows a significant result, PMX 205 (antagonist group) with the value recorded in between 0.02136 to 0.5322[1].
In vivoTg2576 mice are treated with PMX 205 (PMX205) at 20 μg/mL in the drinking water (n=17) from 12 to 15 mo of age, the time frame at which there is a rapid accumulation of amyloid deposits in these animals. Untreated Tg2576 animals (n=11) are used as controls. After 3 mo, animals treated with PMX 205 show significantly less fibrillar plaque load (thioflavine reactivity) than do untreated animals. In 3×Tg mice, PMX 205 also significantly reduces hyperphosphorylated tau (69%)[2].
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 60 mg/ml (66.73 mM)
KeywordsPMX 205 acetate(514814494 free base) | PMX 205 acetate(514814 49 4 free base) | PMX 205 acetate(514814-49-4 free base)
Inhibitors RelatedIptacopan hydrochloride | Dexamethasone | Cyclosporin A | 3-Phenoxybenzaldehyde
Related Compound LibrariesBioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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