PMSF NEW
| Price | $33 | $46 | $48 |
| Package | 50mg | 100mg | 200mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-06 |
Product Details
| Product Name: PMSF | CAS No.: 329-98-6 |
| Purity: 99.9% | Supply Ability: 10g |
| Release date: 2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | PMSF |
| 描述 | Phenylmethanesulfonyl fluoride (PMSF (Phenylmethylsulfonyl fluoride)) is an enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex. |
| 體外活性 | Treatment with PMSF (intraperitoneal injection) in mice elicits cannabinoid-like effects, providing analgesia (ED50: 86 mg/kg), hypothermia (ED50: 224 mg/kg), and catalepsy (ED50: 206 mg/kg). When administered to Sprague-Dawley rats, PMSF induces a dose-dependent analgesic effect and significantly potentiates the analgesic effect of β-endorphin in vivo. By inhibiting fatty acid amide hydrolase (FAAH) activity, PMSF suppresses typical cannabinoid or Δ(9)-tetrahydrocannabinol-like effects in ICR mice. Pretreatment with 30 mg/kg PMSF before the injection of [3H]-labeled cannabinoids results in a notable increase in brain cannabinoid levels after 5 minutes compared to [3H]-THC. PMSF pretreatment at 30 mg/kg enhances the cannabinoid-induced effects on the tail-flick response (analgesic effect), locomotion, and spontaneous activity by 5, 8, and 10-fold respectively. Administering PMSF 12 hours before paraoxon (PSP) protects hens from delayed neurotoxicity, whereas administration 4 hours later exacerbates the neurotoxic effects. PMSF pretreatment also prevents organophosphate-induced delayed neuropathy in hens and inhibits neuropathilament degeneration induced by tri-ortho-tolyl phosphate. |
| 體內(nèi)活性 | PMSF is a specific inhibitor of phospholipase C involved in the hydrolysis of phosphatidylinositol. In the longitudinal smooth muscle of guinea pig ileum, PMSF (2 mM) almost completely inhibits carbachol-activated synthesis of phosphatidylinositol muscarinic, without affecting synthesis activated by potassium. PMSF transiently inhibits muscle contractions induced by both potassium and carbachol. As an acetylcholinesterase inhibitor, PMSF outperforms BSF (at 8 times the concentration of PMSF), with BSF being sixfold less effective. PMSF rapidly inhibits the activity of trypsin purified from the human pancreas and acetylcholinesterase in human erythrocytes but has a negligible effect on human trypsin. In Trypanosoma brucei, PMSF inhibits the addition of ethanolamine phosphate to the intermediate of glycosylphosphatidylinositol and the acylation of the glycosyl residue in the blood GPI intermediates as well as the addition of ethanolamine phosphate and the acylation of glycosyl in the procyclic form, with no inhibition observed on the latter in mammalian HeLa cells. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 17.4 mg/mL (100 mM) DMSO : 55 mg/mL (315.75 mM) |
| 關(guān)鍵字 | PMSF | inhibit | Cathepsin | Benzylsulfonyl Fluoride | Inhibitor | Phenylmethylsulfonyl Fluoride |
| 相關(guān)產(chǎn)品 | Papain | 2-Aminoethanethiol | (S)-(+)-Ibuprofen | Nafamostat mesylate | AEBSF hydrochloride | N-Ethylmaleimide | Aloxistatin | Ceritinib | Aprotinin | Benzamidine hydrochloride |
| 相關(guān)庫 | 高選擇性抑制劑庫 | 表型篩選靶點(diǎn)鑒定庫 | 經(jīng)典已知活性庫 | 蛋白酶抑制劑庫 | 自噬庫 | 抑制劑庫 | 已知活性化合物庫 | 含氟化合物庫 | 抗代謝疾病化合物庫 | 人代謝物化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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