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Postion:Product Catalog >API>Antineoplastic agents>Idiopathic pulmonary fibrosis(IPF)>Pirfenidone
Pirfenidone
  • Pirfenidone

Pirfenidone

Price $9.9
Package 1g
Min. Order: 1g
Supply Ability: 100kg
Update Time: 2024-10-23

Product Details

Product Name: Pirfenidone CAS No.: 53179-13-8
Min. Order: 1g Purity: 99%
Supply Ability: 100kg Release date: 2024/10/23
Basic Information
Name
Pirfenidone
Synonyms
5-Methyl-1-phenyl-2-(1H)-pyridone
Article illustration
Molecular Structure
Article illustration

Molecular Formula
C12H11NO
Molecular Weight
185.22
CAS Registry Number
53179-13-8
Properties
Melting Point
96-97oC
Boiling Point
329.1oC at 760 mmHg
pKa
-0.16±0.63(Predicted)
Appearance
Off-White Solid
Water Solubility
DMSO: ≥10 mg/mL, soluble
Description


Pirfenidone (PFD) is a new pyridinone compound with broad spectrum anti-fibrosis effect, which can prevent and reverse fibrosis and scar formation. Launched in 2008 by Shionogi, Japan, and approved by the US Food and Drug Administration, shionogi is the first drug to demonstrate the efficacy of Chemicalbook in idiopathic pulmonary fibrosis (IPF) through a repetitive, randomized, placebo-controlled phase iii clinical trial. The drug also has a good effect on fibrosis diseases such as renal interstitial fibrosis and liver fibrosis. At the same time, it is also widely used in renal diseases (focal segmental glomerulosclerosis), hypertrophic cardiomyopathy, adult type I multiple neurofibroma, adolescent type I multiple neurofibroma and cluster neurofibroma, diabetes mellitus with kidney disease, uterine leiomyoma phase II clinical research and so on.


Usage


PFD is an effective cytokine inhibitor that inhibits the biological activity of fibroblasts and reduces cell proliferation and matrix collagen synthesis by regulating or inhibiting certain factors. At the same time, PFD can also inhibit the secretion of inflammatory mediators, reduce lipid peroxidation, and play its anti-inflammatory and antioxidant role. 

1. The inhibition of collagen synthesis of fibroblast growth factor (bFGF), transforming growth factor beta (transforminggrowthfactor - beta, TGF - beta), connective tissue growth factor (connectivetissuegrowthfactor, CTGF and metalloproteinase tissue inhibitor 1(TIMP-1) are growth factors related to fibrotic diseases, which can promote the proliferation and growth of fibroblasts, increase the synthesis of matrix collagen and prevent the degradation of extracellular matrix (ECM). They are expressed in different degrees in the process of organ fibrosis. PFD can reduce the expression of bFGF, TGF-β, ChemicalbookCTGF and TIMP-1 in fibroblasts of lung and kidney, and is correlated with collagen synthesis and matrix reduction. The production of type ⅰ and type ⅲ collagen fibers is also closely related to the synthesis of matrix collagen. PFD decreased the expression of TGF-β and the production of type ⅰ collagen. PFD also inhibited the expression of type I collagen in pulmonary fibrosis models. In addition, PFD also inhibits the mRNA expression of type iii collagen, which can reduce the synthesis of type III collagen. 2. Anti-inflammatory effect PFD can inhibit inflammatory mediators to play its anti-inflammatory effect to varying degrees. When the inflammatory factors are overexpressed in the lung, the inflammatory response will be intensified, which thickens the alveolar wall, reduces the alveolar function, and eventually leads to fibrosis. PFD mainly plays an anti-inflammatory role by inhibiting the expression of inflammatory mediators, reducing vascular permeability, and reducing the aggregation of neutrophils and inflammatory cells, so as to prevent or slow down the fibrosis degree of organ tissues. 3. Antioxidant effect PFD exerts its antioxidant effect mainly by scavenging free radicals, inhibiting lipid peroxidation and alleviating oxidative stress.


Advantage:

1. Our company is a professional production leading factory in China in pharmaceutical area of many years. Delivery areas of our products:US, UK, Canada, Australia, Brazil, Russia, Portugal, Latvia, Switzerland, Iceland, Ukraine, Germany, France, Netherlands, Belgium, Peru, Sweden, New Zealand, the Czech Republic, Lithuania, Ireland, Tunisia, Mexico, Greece, Puerto Rico, Thailand, Israel and so on.

Payment method: T/T, Western union, Moneygram.

2. Discreet package.The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also take into consideration.

3. Top quality. High quality guarenteed, once any problem is found, the package would be reshipped for you.

4. Security Shipping: Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.

5. We have stock, so we can delivery quickly at the very day when receive the payment.

6. Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.

7. A discount would be given when you make a large order.

Article illustration

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  • Since: 2023-03-16
  • Address: Room 21, Floor 7, Building 3, SBI Chuangye Street, Dongxin Road, Donghu New Technology Development Z
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