Piracetam NEW
| Price | $45 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Piracetam | CAS No.: 7491-74-9 |
| Purity: 99.72% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Piracetam |
| Description | Piracetam (UCB-6215), a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders. |
| In vitro | Excluding the cerebellum, Piracetam enhances active avoidance learning in aged rats and increases membrane fluidity across all brain regions. A daily dose of 300 mg/kg Piracetam significantly boosts membrane fluidity in certain cerebral areas of aged rats without noticeable effects on juvenile rats. Six weeks of daily administration of 300 mg/kg Piracetam elevates NMDA receptor density in the hippocampus, as well as the density of muscarinic cholinergic receptors in the frontal cortex and striatum, with a slight increase also observed in the hippocampal region. Oral administration of 500 mg/kg Piracetam for 14 consecutive days increases NMDA receptor density by approximately 20% in aged mice and restores the normal affinity of L-glutamate for NMDA receptors. Compared to control and alcohol-fed rats, those treated with Piracetam show a 20% increase in synaptic numbers, suggesting a mechanism of synaptic reorganization at the level of mossy fiber synapses. |
| In vivo | Piracetam, when pre-incubated with lipopolysaccharides (at Piracetam to peptide ratios ranging from 9.6 to 960), can dose-dependently inhibit the peptide-induced release of calcein completely. It has been observed through the reduced anisotropy of the membrane-bound fluorescent probe 1,6-diphenyl-1,3,5-hexatriene (DPH) that Piracetam (< 1.0 mM) can enhance the membrane fluidity of brain cells in aged rats, mice, and humans. Piracetam significantly reduces the fusion and destabilizing effects of Abeta 29-42 in a concentration-dependent manner. Pre-incubating Piracetam with the peptide at a 960 ratio, 20 minutes before introducing Abeta 29-42, fully protected both types of fluorescent probes. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (351.72 mM) H2O : 351.72 mM |
| Keywords | Ionotropic glutamate receptors | Piracetam | iGluR | inhibit | UCB 6215 | UCB6215 | Inhibitor |
| Inhibitors Related | (-)-Aspartic acid | Mephenesin | Decanoic Acid | L-Glutamic acid | glycine | Evans blue | L-Glutamine | Direct Blue 1 | L-Glutamic acid monosodium salt | D-Cycloserine | Linalool | O-Phospho-L-serine |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | NO PAINS Compound Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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