Product Details
| Product Name:
Piclamilast |
CAS No.:
144035-83-6 |
| Purity:
98.28% |
Supply Ability:
10g |
| Release date:
2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Piclamilast |
| 描述 | Piclamilast (RP 73401) is a PDE4 inhibitor. |
| 體外活性 | Piclamilast pre-treatment significantly inhibited the changes in 23 genes via mechanisms involving AP-1 activation and c-Jun phosphorylation at Ser63[1]. The IC50s for Piclamilast was 16 nM and 2 nM in pig aorta and eosinophil soluble, respectively. Piclamilast exhibited IC50 values >100 μM, 40 μM, >100 μM, 14 μM for PDE1, PDE2, PDE3 and PDE5. Respectively[4]. |
| 體內(nèi)活性 | Initial in vivo studies conducted in severe combined immunodeficiency mice transplanted with NB4 leukemia cells indicate that the enhancing effect of piclamilast on ATRA-induced myeloid maturation translates into a therapeutic benefit[2]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 30 mg/mL (78.69 mM), Sonication is recommended.
H2O : ＜ 1 mg/ml (insoluble)
|
| 關鍵字 | RP73401 | RP-73401 | inhibit | Phosphodiesterase (PDE) | AML | RPR73401 | phosphodiesterase | PDE | Piclamilast | RPR-73401 | RAR | Inhibitor | ATRA | cAMP |
| 相關產(chǎn)品 | Theophylline monohydrate | Roflumilast | Theobromine | Apremilast | Isoprenaline hydrochloride | Indomethacin | Icariin | Theophylline | Vardenafil hydrochloride | Doxofylline |
| 相關庫 | 神經(jīng)退行性疾病化合物庫 | 經(jīng)典已知活性庫 | 抗阿爾茨海默癥化合物庫 | ReFRAME 相關化合物庫 | 抑制劑庫 | 代謝化合物庫 | 已知活性化合物庫 | 人代謝物化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States