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Postion:Product Catalog >PHY34
PHY34
  • PHY34

PHY34 NEW

Price $167 $248 $389
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: PHY34 CAS No.: 2130033-55-3
Purity: 98.32% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NamePHY34
DescriptionPHY34 is a late stage autophagy inhibitor with nanomolar level inhibitory effect and anti-tumor activity against high-grade serous ovarian cancer (HGSOC) in vivo.
In vitroIn HGSOC cell lines, PHY34 showed cytotoxicity with IC50 of 4 nM. Its IC50 values in MDA-MB-435 and MDAMB-231 cell lines were 23 nM and 5.2 nM, respectively. In OVCAR3 cells, 100 nM PHY34 increased the level of early and late apoptotic cells [1].
In vivoIn the hollow fiber deflector, PHY34 significantly inhibited the growth of cancer cells; In the transplanted tumor model, PHY34 reduced the ovarian tumor load. The bioavailability of mice was 56.6% after intravenous injection of 0.6 mg/kg, intraperitoneal injection of 1.8 mg/kg or oral administration of 75 mg/kg PHY34, and 2.5% after oral administration. After oral administration, the systemic clearance (CL) was 194.1 L/hr/kg, which was nearly 40 times the liver blood flow of mice, indicating that PHY34 had significant extrahepatic clearance. After oral administration, PHY34 was rapidly absorbed, and Tmax was 0.25 hr [1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMF : 30 mg/mL
DMSO:PBS (pH 7.2) (1:3) : 0.25 mg/mL
DMSO : 90 mg/mL (154.5 mM)
Ethanol : 10 mg/mL
KeywordsPHY 34 | PHY34 | PHY-34
Inhibitors RelatedStavudine | Xylitol | Myricetin | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Curcumin | Oxyresveratrol | Paeonol | Naringin | Gefitinib
Related Compound LibrariesBioactive Compound Library | Anti-Ovarian Cancer Compound Library | Autophagy Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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