Phloretin NEW
| Price | $57 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: Phloretin | CAS No.: 60-82-2 |
| Purity: 99.76% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | Phloretin |
| 描述 | Phloretin (NSC-407292) is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leaves and the Manchurian apricot. It promotes potent antioxidative activities in peroxynitrite scavenging and the inhibition of lipid peroxidation. It has been found to inhibit the growth of several cancer cells and induce apoptosis of B16 melanoma and HL60 human leukemia cells. |
| 體外活性 | Phloretin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2, though the inhibition is weaker than by its glycoside phlorizin. [1] Orally consumed phlorizin is nearly entirely converted into phloretin by hydrolytic enzymes in the small intestine. An important effect of this is the inhibition of glucose absorption by the small intestine and the inhibition of renal glucose reabsorption. [2] [3] Phloretin also inhibits a variety of urea transporters. It induces urea loss and diuresis when coupled with high protein diets. [4] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 48 mg/mL (175 mM) DMSO : 55 mg/mL (200.53 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) |
| 關(guān)鍵字 | SGLT | RJC-02792 | inhibit | NSC-407292 | Sodium-dependent glucose cotransporters | Inhibitor | Glucose transporter | NSC407292 | Phloretin | GLUT | RJC02792 | Endogenous Metabolite |
| 相關(guān)庫 | 抗癌天然產(chǎn)物庫 | 黃酮類天然產(chǎn)物庫 | 中藥單體化合物庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 中藥抗炎分子庫 | 高通量篩選天然產(chǎn)物庫 | 已知活性化合物庫 | GPCR靶點分子庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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