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Postion:Product Catalog >PF429242 dihydrochloride
PF429242 dihydrochloride
  • PF429242 dihydrochloride

PF429242 dihydrochloride NEW

Price $36 $85 $123
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: PF429242 dihydrochloride CAS No.: 2248666-66-0
Purity: 98.67% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NamePF429242 dihydrochloride
DescriptionPF429242 dihydrochloride is a reversible and competitive inhibitor of S1P, with an IC50 of 175 nM.
In vitro10 μM PF-429242 down-regulates the signal from an SRE-luciferase reporter gene in human embryonic kidney 293 cells and the expression of endogenous SREBP target genes in cultured HepG2 cells. In HepG2 cells, PF-429242 inhibits cholesterol synthesis, with an IC50 of 0.5 μM[1]. PF-429242 treatment also shows suppressive effects on DENV2 yields in the cultured fluids of human-derived HEK-293, Hep G2, and non-human-primate derived LLC-MK2 cells[2]. PF-429242 has potent antiviral against LCMV and LASV [3].
In vivoPF-429242 inhibits the expression of hepatic SREBP target genes, and the hepatic rates of cholesterol and fatty acid synthesis are reduced In mice[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationH2O : 50 mg/mL (103.63 mM), Sonication is recommended.
DMSO : 83.3 mg/mL (165.81 mM)
KeywordsPF429242 | PF-429242 Dihydrochloride | PF-429242 dihydrochloride | PF429242 dihydrochloride | Virus Protease | inhibit | Inhibitor | PF 429242 Dihydrochloride | PF-429242 | Fatty Acid Synthase (FASN) | PF 429242 | PF429242 Dihydrochloride
Inhibitors RelatedFingolimod hydrochloride | SLP9101555 | SKI-178 | BMS-960 | LX-2931 | K145 hydrochloride | ASP-4058 | Ceranib-2 | Siponimod | Fingolimod | MP-A08 | Ozanimod
Related Compound LibrariesBioactive Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Infection Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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