PF429242 dihydrochloride NEW
Price | $36 | $85 | $123 |
Package | 1mg | 5mg | 10mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-19 |
Product Details
Product Name: PF429242 dihydrochloride | CAS No.: 2248666-66-0 |
Purity: 98.67% | Supply Ability: 10g |
Release date: 2024/11/19 |
Product Introduction
Bioactivity
Name | PF429242 dihydrochloride |
Description | PF429242 dihydrochloride is a reversible and competitive inhibitor of S1P, with an IC50 of 175 nM. |
In vitro | 10 μM PF-429242 down-regulates the signal from an SRE-luciferase reporter gene in human embryonic kidney 293 cells and the expression of endogenous SREBP target genes in cultured HepG2 cells. In HepG2 cells, PF-429242 inhibits cholesterol synthesis, with an IC50 of 0.5 μM[1]. PF-429242 treatment also shows suppressive effects on DENV2 yields in the cultured fluids of human-derived HEK-293, Hep G2, and non-human-primate derived LLC-MK2 cells[2]. PF-429242 has potent antiviral against LCMV and LASV [3]. |
In vivo | PF-429242 inhibits the expression of hepatic SREBP target genes, and the hepatic rates of cholesterol and fatty acid synthesis are reduced In mice[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | H2O : 50 mg/mL (103.63 mM), Sonication is recommended. DMSO : 83.3 mg/mL (165.81 mM) |
Keywords | PF429242 | PF-429242 Dihydrochloride | PF-429242 dihydrochloride | PF429242 dihydrochloride | Virus Protease | inhibit | Inhibitor | PF 429242 Dihydrochloride | PF-429242 | Fatty Acid Synthase (FASN) | PF 429242 | PF429242 Dihydrochloride |
Inhibitors Related | Fingolimod hydrochloride | SLP9101555 | SKI-178 | BMS-960 | LX-2931 | K145 hydrochloride | ASP-4058 | Ceranib-2 | Siponimod | Fingolimod | MP-A08 | Ozanimod |
Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Infection Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
Product name | Price | Suppliers | Update time | |
---|---|---|---|---|
$339.00/1kg |
VIP4Y
|
Shanghai UCHEM Inc.
|
2023-11-16 | |
$1.00/1kg |
VIP4Y
|
Dorne Chemical Technology co. LTD
|
2024-03-26 | |
$180.00/1kg |
VIP1Y
|
Hebei Zhuanglai Chemical Trading Co.,Ltd
|
2024-06-03 | |
$36.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY