Pentamidine dihydrochloride NEW
| Price | $50 | $75 | $128 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: Pentamidine dihydrochloride | CAS No.: 50357-45-4 |
| Purity: 98.58% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | Pentamidine dihydrochloride |
| 描述 | Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent effective against various microorganisms, including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi (Pneumocystis jirovecii). It is a potent and selective inhibitor of protein tyrosine phosphatases and phosphatase of regenerating liver. Pentamidine dihydrochloride inhibits the parasite Leishmania infantum with an IC50 of 2.5 μM. |
| 體外活性 | Pentamidine at its therapeutic doses inhibited recombinant PRL phosphatases in vitro and inactivated ectopically expressed PRLs in NIH3T3 transfectants with an effective duration more than 24 h after a pulse cell treatment[3]. |
| 體內(nèi)活性 | Pentamidine at a tolerable dose markedly inhibited the growth of WM9 human melanoma tumors in nude mice coincident with the induction of tumor cell necrosis and is capable of inactivating ectopically expressed PRL-2 in the cancer cells[3]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 4.13 mg/mL (10 mM), Sonication is recommended. |
| 關(guān)鍵字 | PTP1B | Pneumocystis | Parasite | Antibiotic | Pentamidine | MP601205 | antitumor | Inhibitor | Kidney | carinii | Bacterial | cell-cycle | pneumonia | Phosphatase | inhibit | MP 601205 | MP-601205 | DNA | Pentamidine dihydrochloride | MP 601205 Dihydrochloride | MP601205 Dihydrochloride | Pentamidine Dihydrochloride | biosynthetics | MP-601205 Dihydrochloride | Fungal | arrest |
| 相關(guān)產(chǎn)品 | Neomycin sulfate | Kanamycin sulfate | Sulfamethoxazole sodium | Hydroxychloroquine | Doxycycline | Dimethyl sulfoxide |
| 相關(guān)庫 | 抗寄生蟲庫 | 經(jīng)典已知活性庫 | 抗癌臨床化合物庫 | 抗真菌庫 | 藥物功能重定位化合物庫 | 抗病毒庫 | 抑制劑庫 | FDA 上市藥物庫 | 已知活性化合物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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